Matches in SemOpenAlex for { <https://semopenalex.org/work/W4380996301> ?p ?o ?g. }
- W4380996301 abstract "Epigenetic mechanisms are mandatory for endothelial called lymphangioblasts during cardiovascular development. Dot1l-mediated gene transcription in mice is essential for the development and function of lymphatic ECs (LECs). The role of Dot1l in the development and function of blood ECs blood endothelial cells is unclear. RNA-seq datasets from Dot1l-depleted or -overexpressing BECs and LECs were used to comprehensively analyze regulatory networks of gene transcription and pathways. Dot1l depletion in BECs changed the expression of genes involved in cell-to-cell adhesion and immunity-related biological processes. Dot1l overexpression modified the expression of genes involved in different types of cell-to-cell adhesion and angiogenesis-related biological processes. Genes involved in specific tissue development-related biological pathways were altered in Dot1l-depleted BECs and LECs. Dot1l overexpression altered ion transportation-related genes in BECs and immune response regulation-related genes in LECs. Importantly, Dot1l overexpression in BECs led to the expression of genes related to the angiogenesis and increased expression of MAPK signaling pathways related was found in both Dot1l-overexpressing BECs and LECs. Therefore, our integrated analyses of transcriptomics in Dot1l-depleted and Dot1l-overexpressed ECs demonstrate the unique transcriptomic program of ECs and the differential functions of Dot1l in the regulation of gene transcription in BECs and LECs." @default.
- W4380996301 created "2023-06-17" @default.
- W4380996301 creator A5023388384 @default.
- W4380996301 creator A5025661373 @default.
- W4380996301 creator A5031182810 @default.
- W4380996301 creator A5038730104 @default.
- W4380996301 creator A5076184471 @default.
- W4380996301 creator A5078134461 @default.
- W4380996301 creator A5081376794 @default.
- W4380996301 creator A5085196309 @default.
- W4380996301 creator A5085863865 @default.
- W4380996301 date "2023-06-15" @default.
- W4380996301 modified "2023-09-27" @default.
- W4380996301 title "Common and distinct functions of mouse Dot1l in the regulation of endothelial transcriptome" @default.
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