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- W4380996486 endingPage "4761" @default.
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- W4380996486 abstract "Opioids are considered the most effective analgesics for the treatment of moderate to severe acute and chronic pain. However, the inadequate benefit/risk ratio of currently available opioids, together with the current 'opioid crisis', warrant consideration on new opioid analgesic discovery strategies. Targeting peripheral opioid receptors as effective means of treating pain and avoiding the centrally mediated side effects represents a research area of substantial and continuous attention. Among clinically used analgesics, opioids from the class of morphinans (i.e., morphine and structurally related analogues) are of utmost clinical importance as analgesic drugs activating the mu-opioid receptor. In this review, we focus on peripheralization strategies applied to N-methylmorphinans to limit their ability to cross the blood-brain barrier, thus minimizing central exposure and the associated undesired side effects. Chemical modifications to the morphinan scaffold to increase hydrophilicity of known and new opioids, and nanocarrier-based approaches to selectively deliver opioids, such as morphine, to the peripheral tissue are discussed. The preclinical and clinical research activities have allowed for the characterization of a variety of compounds that show low central nervous system penetration, and therefore an improved side effect profile, yet maintaining the desired opioid-related antinociceptive activity. Such peripheral opioid analgesics may represent alternatives to presently available drugs for an efficient and safer pain therapy." @default.
- W4380996486 created "2023-06-17" @default.
- W4380996486 creator A5002878894 @default.
- W4380996486 creator A5005827647 @default.
- W4380996486 creator A5022198549 @default.
- W4380996486 creator A5078205952 @default.
- W4380996486 date "2023-06-14" @default.
- W4380996486 modified "2023-09-27" @default.
- W4380996486 title "Peripheralization Strategies Applied to Morphinans and Implications for Improved Treatment of Pain" @default.
- W4380996486 cites W1575997529 @default.
- W4380996486 cites W1591635240 @default.
- W4380996486 cites W1829332936 @default.
- W4380996486 cites W1831470967 @default.
- W4380996486 cites W1963627122 @default.
- W4380996486 cites W1972231366 @default.
- W4380996486 cites W1975005339 @default.
- W4380996486 cites W1980826088 @default.
- W4380996486 cites W1983472018 @default.
- W4380996486 cites W1988193392 @default.
- W4380996486 cites W1996117997 @default.
- W4380996486 cites W1998133033 @default.
- W4380996486 cites W1999329953 @default.
- W4380996486 cites W2000043780 @default.
- W4380996486 cites W2002219509 @default.
- W4380996486 cites W2013797651 @default.
- W4380996486 cites W2015554884 @default.
- W4380996486 cites W2020841428 @default.
- W4380996486 cites W2021893815 @default.
- W4380996486 cites W2022272379 @default.
- W4380996486 cites W2022561997 @default.
- W4380996486 cites W2023285519 @default.
- W4380996486 cites W2024998401 @default.
- W4380996486 cites W2028614075 @default.
- W4380996486 cites W2033381165 @default.
- W4380996486 cites W2036377137 @default.
- W4380996486 cites W2040071171 @default.
- W4380996486 cites W2040349855 @default.
- W4380996486 cites W2056170840 @default.
- W4380996486 cites W2058271101 @default.
- W4380996486 cites W2060225266 @default.
- W4380996486 cites W2060435731 @default.
- W4380996486 cites W2068307036 @default.
- W4380996486 cites W2076914157 @default.
- W4380996486 cites W2082081080 @default.
- W4380996486 cites W2087296596 @default.
- W4380996486 cites W2088062002 @default.
- W4380996486 cites W2089827399 @default.
- W4380996486 cites W2094835720 @default.
- W4380996486 cites W2097912054 @default.
- W4380996486 cites W2098089039 @default.
- W4380996486 cites W2102818262 @default.
- W4380996486 cites W2107224500 @default.
- W4380996486 cites W2113426456 @default.
- W4380996486 cites W2122566819 @default.
- W4380996486 cites W2125769182 @default.
- W4380996486 cites W2126365526 @default.
- W4380996486 cites W2132804094 @default.
- W4380996486 cites W2138295551 @default.
- W4380996486 cites W2143651267 @default.
- W4380996486 cites W2148852974 @default.
- W4380996486 cites W2154539500 @default.
- W4380996486 cites W2156662567 @default.
- W4380996486 cites W2159430466 @default.
- W4380996486 cites W2162476338 @default.
- W4380996486 cites W2167484671 @default.
- W4380996486 cites W2168086897 @default.
- W4380996486 cites W2179384912 @default.
- W4380996486 cites W2215793390 @default.
- W4380996486 cites W2224446920 @default.
- W4380996486 cites W2280336365 @default.
- W4380996486 cites W2318080502 @default.
- W4380996486 cites W2477848739 @default.
- W4380996486 cites W2519186099 @default.
- W4380996486 cites W2582436751 @default.
- W4380996486 cites W2587222353 @default.
- W4380996486 cites W2588773694 @default.
- W4380996486 cites W2607108995 @default.
- W4380996486 cites W2613283344 @default.
- W4380996486 cites W2725097790 @default.
- W4380996486 cites W2733705929 @default.
- W4380996486 cites W2776314647 @default.
- W4380996486 cites W2800256118 @default.
- W4380996486 cites W2802847947 @default.
- W4380996486 cites W2806465603 @default.
- W4380996486 cites W2808792445 @default.
- W4380996486 cites W2889007783 @default.
- W4380996486 cites W2896053285 @default.
- W4380996486 cites W2905837233 @default.
- W4380996486 cites W2939844444 @default.
- W4380996486 cites W3009490944 @default.
- W4380996486 cites W3012433284 @default.
- W4380996486 cites W3012437546 @default.
- W4380996486 cites W3030967305 @default.
- W4380996486 cites W3081159464 @default.
- W4380996486 cites W3138265059 @default.
- W4380996486 cites W3199848553 @default.
- W4380996486 cites W3211040763 @default.
- W4380996486 cites W40809878 @default.