Matches in SemOpenAlex for { <https://semopenalex.org/work/W4380996771> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W4380996771 abstract "Lurbinectedin is a selective inhibitor of oncogenic transcription U.S. Food and Drug Administration (FDA)-approved for patients with relapsed small cell lung cancer (SCLC) as monotherapy at 3.2 mg/m2 every 3 weeks (q3wk). ATLANTIS was a phase 3 study in SCLC with lurbinectedin 2.0 mg/m2 plus doxorubicin 40 mg/m2 q3wk vs physician's choice, with overall survival (OS) as the primary endpoint and objective response rate (ORR) as the secondary endpoint. This work aimed to dissect the contribution of lurbinectedin and doxorubicin to antitumor effects in SCLC, and to predict the efficacy of single-agent lurbinectedin at 3.2 mg/m2 in ATLANTIS to allow for a head-to-head comparison with the control arm.The dataset included exposure and efficacy data from 387 patients with relapsed SCLC (ATLANTIS, n=288; study B-005, n=99). Patients in the ATLANTIS control arm (n=289) were used for comparison. Unbound plasma lurbinectedin area under the concentration-time curve (AUCu) and total plasma doxorubicin area under the concentration-time curve (AUCDOX) were used as exposure metrics. Univariate and multivariate analyses were conducted to determine the best predictors and predictive model for OS and ORR. OS baseline hazard was best described by a log-logistic distribution, with chemotherapy-free interval (CTFI), lactate dehydrogenase, albumin, brain metastases, neutrophils/lymphocytes ratio, AUCu, and the interaction between AUCu and AUCDOX as predictors. Effect of AUCu on ORR best fitted to a sigmoid-maximal response (Emax) logistic model, where Emax was dependent on CTFI.Head-to-head comparisons with predicted 3.2 mg/m2 lurbinectedin resulted in a positive outcome in ATLANTIS, with hazard ratio (95% prediction intervals [95% PI]) for OS of 0.54 (0.41, 0.72), and odds ratio (95% PI) for ORR of 0.35 (0.25, 0.5).These results support the superiority of lurbinectedin monotherapy for relapsed SCLC over other approved therapies." @default.
- W4380996771 created "2023-06-17" @default.
- W4380996771 creator A5007573955 @default.
- W4380996771 creator A5016698105 @default.
- W4380996771 creator A5030621386 @default.
- W4380996771 creator A5036714492 @default.
- W4380996771 creator A5083698345 @default.
- W4380996771 date "2023-06-15" @default.
- W4380996771 modified "2023-10-18" @default.
- W4380996771 title "A model-based head-to-head comparison of single-agent lurbinectedin in the pivotal ATLANTIS Study" @default.
- W4380996771 cites W1603105736 @default.
- W4380996771 cites W2000666384 @default.
- W4380996771 cites W2024661879 @default.
- W4380996771 cites W2062859912 @default.
- W4380996771 cites W2329743822 @default.
- W4380996771 cites W2567690584 @default.
- W4380996771 cites W2725758645 @default.
- W4380996771 cites W2886110422 @default.
- W4380996771 cites W3013383466 @default.
- W4380996771 cites W3157382973 @default.
- W4380996771 cites W3210073698 @default.
- W4380996771 cites W4220706225 @default.
- W4380996771 cites W4293877477 @default.
- W4380996771 cites W4306247391 @default.
- W4380996771 cites W64171703 @default.
- W4380996771 doi "https://doi.org/10.3389/fonc.2023.1152371" @default.
- W4380996771 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37397388" @default.
- W4380996771 hasPublicationYear "2023" @default.
- W4380996771 type Work @default.
- W4380996771 citedByCount "0" @default.
- W4380996771 crossrefType "journal-article" @default.
- W4380996771 hasAuthorship W4380996771A5007573955 @default.
- W4380996771 hasAuthorship W4380996771A5016698105 @default.
- W4380996771 hasAuthorship W4380996771A5030621386 @default.
- W4380996771 hasAuthorship W4380996771A5036714492 @default.
- W4380996771 hasAuthorship W4380996771A5083698345 @default.
- W4380996771 hasBestOaLocation W43809967711 @default.
- W4380996771 hasConcept C105795698 @default.
- W4380996771 hasConcept C126322002 @default.
- W4380996771 hasConcept C143998085 @default.
- W4380996771 hasConcept C151956035 @default.
- W4380996771 hasConcept C161584116 @default.
- W4380996771 hasConcept C199163554 @default.
- W4380996771 hasConcept C203092338 @default.
- W4380996771 hasConcept C207103383 @default.
- W4380996771 hasConcept C2776694085 @default.
- W4380996771 hasConcept C2781303535 @default.
- W4380996771 hasConcept C33923547 @default.
- W4380996771 hasConcept C44249647 @default.
- W4380996771 hasConcept C535046627 @default.
- W4380996771 hasConcept C71924100 @default.
- W4380996771 hasConcept C98274493 @default.
- W4380996771 hasConceptScore W4380996771C105795698 @default.
- W4380996771 hasConceptScore W4380996771C126322002 @default.
- W4380996771 hasConceptScore W4380996771C143998085 @default.
- W4380996771 hasConceptScore W4380996771C151956035 @default.
- W4380996771 hasConceptScore W4380996771C161584116 @default.
- W4380996771 hasConceptScore W4380996771C199163554 @default.
- W4380996771 hasConceptScore W4380996771C203092338 @default.
- W4380996771 hasConceptScore W4380996771C207103383 @default.
- W4380996771 hasConceptScore W4380996771C2776694085 @default.
- W4380996771 hasConceptScore W4380996771C2781303535 @default.
- W4380996771 hasConceptScore W4380996771C33923547 @default.
- W4380996771 hasConceptScore W4380996771C44249647 @default.
- W4380996771 hasConceptScore W4380996771C535046627 @default.
- W4380996771 hasConceptScore W4380996771C71924100 @default.
- W4380996771 hasConceptScore W4380996771C98274493 @default.
- W4380996771 hasLocation W43809967711 @default.
- W4380996771 hasLocation W43809967712 @default.
- W4380996771 hasLocation W43809967713 @default.
- W4380996771 hasOpenAccess W4380996771 @default.
- W4380996771 hasPrimaryLocation W43809967711 @default.
- W4380996771 hasRelatedWork W1900595920 @default.
- W4380996771 hasRelatedWork W2114624491 @default.
- W4380996771 hasRelatedWork W2194631636 @default.
- W4380996771 hasRelatedWork W2793335702 @default.
- W4380996771 hasRelatedWork W2889691785 @default.
- W4380996771 hasRelatedWork W2900720404 @default.
- W4380996771 hasRelatedWork W2957457613 @default.
- W4380996771 hasRelatedWork W3004966710 @default.
- W4380996771 hasRelatedWork W3005203090 @default.
- W4380996771 hasRelatedWork W4362432942 @default.
- W4380996771 hasVolume "13" @default.
- W4380996771 isParatext "false" @default.
- W4380996771 isRetracted "false" @default.
- W4380996771 workType "article" @default.