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- W4381046738 abstract "Schwann cells (SCs) support peripheral nerves under homeostatic conditions, independent of myelination, and contribute to damage in prediabetic peripheral neuropathy (PN). Here, we used single-cell RNA sequencing to characterize the transcriptional profiles and intercellular communication of SCs in the nerve microenvironment using the high-fat diet-fed mouse, which mimics human prediabetes and neuropathy. We identified four major SC clusters, myelinating, nonmyelinating, immature, and repair in healthy and neuropathic nerves, in addition to a distinct cluster of nerve macrophages. Myelinating SCs acquired a unique transcriptional profile, beyond myelination, in response to metabolic stress. Mapping SC intercellular communication identified a shift in communication, centered on immune response and trophic support pathways, which primarily impacted nonmyelinating SCs. Validation analyses revealed that neuropathic SCs become pro-inflammatory and insulin resistant under prediabetic conditions. Overall, our study offers a unique resource for interrogating SC function, communication, and signaling in nerve pathophysiology to help inform SC-specific therapies." @default.
- W4381046738 created "2023-06-18" @default.
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- W4381046738 date "2023-06-16" @default.
- W4381046738 modified "2023-10-16" @default.
- W4381046738 title "Single‐cell <scp>RNA</scp>‐seq uncovers novel metabolic functions of Schwann cells beyond myelination" @default.
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- W4381046738 doi "https://doi.org/10.1111/jnc.15877" @default.
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