Matches in SemOpenAlex for { <https://semopenalex.org/work/W4381053751> ?p ?o ?g. }
- W4381053751 abstract "Abstract Background The remarkable resistance to ionizing radiation found in anhydrobiotic organisms, such as some bacteria, tardigrades, and bdelloid rotifers has been hypothesized to be incidental to the desiccation resistance. Both stresses produce reactive oxygen species and cause damage to DNA and other macromolecules, including DNA. However, this hypothesis has only been investigated in a few species and it is so far not possible to determine how universal it is. Results In this study, we analyzed the transcriptomic response of the bdelloid rotifer Adineta vaga to desiccation and to low-(X-rays) and high-(Fe) LET radiation in order to highlight the molecular and genetic mechanisms triggered by both stresses. We detected a transcriptomic response common to desiccation and both radiations with the over-expression of highly expressed genes mainly involved in DNA repair, protein modifications, or coding for Heat Shock Proteins, histones variants, enhancers but also many genes with unknown functions. We also discovered a distinct transcriptomic response specific to rehydration, which involved the over-expression of genes encoding Late Embryogenesis Abundant proteins, Heat Shock Proteins, and glucose repressive proteins. Moreover, we identified numerous genes encoding antioxidants that are constitutively highly expressed, which may contribute to the bdelloid rotifer resistance. Conclusions These results suggest that the extreme resistance of bdelloid rotifers to radiation might indeed be inherited from and a consequence of their capacity to resist complete desiccation. This study paves the way for functional experiments targeting promising candidate proteins playing central roles in radiation and desiccation resistance." @default.
- W4381053751 created "2023-06-18" @default.
- W4381053751 creator A5011254029 @default.
- W4381053751 creator A5023413695 @default.
- W4381053751 creator A5023618347 @default.
- W4381053751 creator A5027227340 @default.
- W4381053751 creator A5031072629 @default.
- W4381053751 creator A5036683181 @default.
- W4381053751 creator A5059577037 @default.
- W4381053751 creator A5061793701 @default.
- W4381053751 creator A5075748049 @default.
- W4381053751 creator A5077460598 @default.
- W4381053751 creator A5082441764 @default.
- W4381053751 date "2023-06-16" @default.
- W4381053751 modified "2023-10-01" @default.
- W4381053751 title "Ionizing radiation responses are incidental to desiccation responses in the bdelloid rotifer<i>Adineta vaga</i>" @default.
- W4381053751 cites W1502872641 @default.
- W4381053751 cites W1548566755 @default.
- W4381053751 cites W1581648226 @default.
- W4381053751 cites W1892057968 @default.
- W4381053751 cites W1968825812 @default.
- W4381053751 cites W1971411881 @default.
- W4381053751 cites W1972121275 @default.
- W4381053751 cites W1973340310 @default.
- W4381053751 cites W1975235151 @default.
- W4381053751 cites W1983642662 @default.
- W4381053751 cites W1984194161 @default.
- W4381053751 cites W1984736575 @default.
- W4381053751 cites W1987211450 @default.
- W4381053751 cites W1987984651 @default.
- W4381053751 cites W1993053406 @default.
- W4381053751 cites W1997679750 @default.
- W4381053751 cites W1999470057 @default.
- W4381053751 cites W2001461288 @default.
- W4381053751 cites W2002349234 @default.
- W4381053751 cites W2007069369 @default.
- W4381053751 cites W2010554711 @default.
- W4381053751 cites W2012053348 @default.
- W4381053751 cites W2018346130 @default.
- W4381053751 cites W2019988726 @default.
- W4381053751 cites W2020697796 @default.
- W4381053751 cites W2020813760 @default.
- W4381053751 cites W2022366078 @default.
- W4381053751 cites W2023547639 @default.
- W4381053751 cites W2024185147 @default.
- W4381053751 cites W2024310585 @default.
- W4381053751 cites W2028907870 @default.
- W4381053751 cites W2029761012 @default.
- W4381053751 cites W2030597563 @default.
- W4381053751 cites W2032080066 @default.
- W4381053751 cites W2038933702 @default.
- W4381053751 cites W2039111756 @default.
- W4381053751 cites W2041054640 @default.
- W4381053751 cites W2043239551 @default.
- W4381053751 cites W2043415528 @default.
- W4381053751 cites W2051148648 @default.
- W4381053751 cites W2051459519 @default.
- W4381053751 cites W2053650579 @default.
- W4381053751 cites W2054248299 @default.
- W4381053751 cites W2061449283 @default.
- W4381053751 cites W2065087624 @default.
- W4381053751 cites W2067829962 @default.
- W4381053751 cites W2068642632 @default.
- W4381053751 cites W2070409482 @default.
- W4381053751 cites W2073232799 @default.
- W4381053751 cites W2074853081 @default.
- W4381053751 cites W2074910388 @default.
- W4381053751 cites W2075627332 @default.
- W4381053751 cites W2081188860 @default.
- W4381053751 cites W2086137541 @default.
- W4381053751 cites W2086389710 @default.
- W4381053751 cites W2086727854 @default.
- W4381053751 cites W2087161387 @default.
- W4381053751 cites W2087689873 @default.
- W4381053751 cites W2091577612 @default.
- W4381053751 cites W2091735226 @default.
- W4381053751 cites W2095665485 @default.
- W4381053751 cites W2095755077 @default.
- W4381053751 cites W2097966092 @default.
- W4381053751 cites W2101196698 @default.
- W4381053751 cites W2102752109 @default.
- W4381053751 cites W2104257107 @default.
- W4381053751 cites W2113022735 @default.
- W4381053751 cites W2113777563 @default.
- W4381053751 cites W2114104545 @default.
- W4381053751 cites W2114860261 @default.
- W4381053751 cites W2116726085 @default.
- W4381053751 cites W2116967350 @default.
- W4381053751 cites W2117181072 @default.
- W4381053751 cites W2120556763 @default.
- W4381053751 cites W2122332873 @default.
- W4381053751 cites W2126386203 @default.
- W4381053751 cites W2129010599 @default.
- W4381053751 cites W2130116522 @default.
- W4381053751 cites W2130430382 @default.
- W4381053751 cites W2131209367 @default.
- W4381053751 cites W2133959309 @default.
- W4381053751 cites W2134218960 @default.
- W4381053751 cites W2134526812 @default.
- W4381053751 cites W2134640426 @default.