Matches in SemOpenAlex for { <https://semopenalex.org/work/W4381094014> ?p ?o ?g. }
- W4381094014 abstract "Abstract Follicular helper T (Tfh) cells are essential for germinal center (GC) B cell responses. However, it is not clear which PD-1 + CXCR5 + Bcl6 + CD4 + T cells will differentiate into PD-1 hi CXCR5 hi Bcl6 hi GC-Tfh cells and how GC-Tfh cell differentiation is regulated. Here, we report that the sustained Tigit expression in PD-1 + CXCR5 + CD4 + T cells marks the precursor Tfh (pre-Tfh) to GC-Tfh transition, whereas Tigit – PD-1 + CXCR5 + CD4 + T cells upregulate IL-7Rα to become CXCR5 + CD4 + T memory cells with or without CCR7. We demonstrate that pre-Tfh cells undergo substantial further differentiation at the transcriptome and chromatin accessibility levels to become GC-Tfh cells. The transcription factor c-Maf appears critical in governing the pre-Tfh to GC-Tfh transition, and we identify Plekho1 as a stage-specific downstream factor regulating the GC-Tfh competitive fitness. In summary, our work identifies an important marker and regulatory mechanism of PD-1 + CXCR5 + CD4 + T cells during their developmental choice between memory T cell fate and GC-Tfh cell differentiation." @default.
- W4381094014 created "2023-06-18" @default.
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- W4381094014 date "2023-06-17" @default.
- W4381094014 modified "2023-10-17" @default.
- W4381094014 title "Spatiotemporal resolution of germinal center Tfh cell differentiation and divergence from central memory CD4+ T cell fate" @default.
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- W4381094014 doi "https://doi.org/10.1038/s41467-023-39299-3" @default.
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- W4381094014 hasPublicationYear "2023" @default.
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