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• W4381112866 abstract "<h3>Introduction</h3> The UK NICE (National Institute for Health & Care Excellence) DG27 guidelines recommends universal testing for Lynch syndrome (LS) in all newly diagnosed Colorectal Cancer (CRC) cases. However, implementation of the DG27 guideline varies significantly by geography. This Quality Improvement Project (QIP) was developed to measure variation and deliver an effective diagnostic pathway from diagnosis of CRC to diagnosis of LS within the RM Partners (RMP) cancer alliance geography. <h3>Methods</h3> RMP covers a population of 4 million people and incorporates 9 CRC multidisciplinary teams (MDT) overseen by a Pathway Group, and 3 regional genetic services, managing approximately 1500 new CRC cases annually. A responsible LS champion was nominated within each MDT. A regional project manager and nurse practitioner were appointed to support the LS champions, to develop training packages and patient consultation workshops. MDTs were supported to develop an ‘in-house’ mainstreaming service to offer genetic testing in their routine oncology clinics. Baseline data was collected through completion of the QIP audit of the LS testing pathway in 30 consecutive CRC patients from each MDT. This information identified areas for improvement in each MDT. <h3>Results</h3> In baseline audit the first step of the testing pathway, tumour mismatch repair testing, was performed in 93% of 270 CRC patients. However only 23% (7/30) of eligible patients underwent methylation testing, and only 9% (2/22) eligible for constitutional testing were referred to a genetics service, with high levels of variation between each MDT. During the QIP we have developed new mainstreaming services and demonstrated implementation of systematic and robust testing pathways across the cancer alliance. We have implemented systematic approaches to facilitate identification and diagnosis of eligible patients for LS testing after CRC diagnosis across each cancer team. <h3>Conclusions</h3> The LS project was completed in April 2022. This work has led to the development of a new NICE standard QS20 which recommends local leadership within cancer teams to ensure delivery of diagnosis of LS. We have implemented a systematic approach with workforce transformation to facilitate identification and ‘mainstreamed’ genetic diagnosis of LS. This programme has now evolved to be one of the UK national genomics transformational projects which will integrate genomics into clinical practice." @default.
• W4381112866 created "2023-06-19" @default.
• W4381112866 creator A5090816624 @default.
• W4381112866 date "2023-06-01" @default.
• W4381112866 modified "2023-09-27" @default.
• W4381112866 title "P343 From diagnosis of colorectal cancer to diagnosis of lynch syndrome: the RM partners quality improvement project" @default.
• W4381112866 doi "https://doi.org/10.1136/gutjnl-2023-bsg.407" @default.
• W4381112866 hasPublicationYear "2023" @default.
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