FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4381122167> ?p ?o ?g. }

• W4381122167 abstract "Abstract Astrocytes respond to traumatic brain injury (TBI) with changes to their molecular make‐up and cell biology, which results in changes in astrocyte function. These changes can be adaptive, initiating repair processes in the brain, or detrimental, causing secondary damage including neuronal death or abnormal neuronal activity. The response of astrocytes to TBI is often—but not always—accompanied by the upregulation of intermediate filaments, including glial fibrillary acidic protein (GFAP) and vimentin. Because GFAP is often upregulated in the context of nervous system disturbance, reactive astrogliosis is sometimes treated as an “all‐or‐none” process. However, the extent of astrocytes' cellular, molecular, and physiological adjustments is not equal for each TBI type or even for each astrocyte within the same injured brain. Additionally, new research highlights that different neurological injuries and diseases result in entirely distinctive and sometimes divergent astrocyte changes. Thus, extrapolating findings on astrocyte biology from one pathological context to another is problematic. We summarize the current knowledge about astrocyte responses specific to TBI and point out open questions that the field should tackle to better understand how astrocytes shape TBI outcomes. We address the astrocyte response to focal versus diffuse TBI and heterogeneity of reactive astrocytes within the same brain, the role of intermediate filament upregulation, functional changes to astrocyte function including potassium and glutamate homeostasis, blood–brain barrier maintenance and repair, metabolism, and reactive oxygen species detoxification, sex differences, and factors influencing astrocyte proliferation after TBI. This article is categorized under: Neurological Diseases > Molecular and Cellular Physiology" @default.
• W4381122167 created "2023-06-19" @default.
• W4381122167 creator A5072268036 @default.
• W4381122167 creator A5081543240 @default.
• W4381122167 date "2023-06-18" @default.
• W4381122167 modified "2023-10-17" @default.
• W4381122167 title "Astrocyte‐mediated mechanisms contribute to traumatic brain injury pathology" @default.
• W4381122167 cites W1543151032 @default.
• W4381122167 cites W1671523129 @default.
• W4381122167 cites W1965317564 @default.
• W4381122167 cites W1967246939 @default.
• W4381122167 cites W1969619562 @default.
• W4381122167 cites W1969713114 @default.
• W4381122167 cites W1971119506 @default.
• W4381122167 cites W1978008817 @default.
• W4381122167 cites W1979228875 @default.
• W4381122167 cites W1981893433 @default.
• W4381122167 cites W1982954912 @default.
• W4381122167 cites W1984050978 @default.
• W4381122167 cites W1987471048 @default.
• W4381122167 cites W1989217312 @default.
• W4381122167 cites W1998314033 @default.
• W4381122167 cites W2002897207 @default.
• W4381122167 cites W2003540939 @default.
• W4381122167 cites W2005896958 @default.
• W4381122167 cites W2005950079 @default.
• W4381122167 cites W2012893265 @default.
• W4381122167 cites W2016818296 @default.
• W4381122167 cites W2019308992 @default.
• W4381122167 cites W2019793985 @default.
• W4381122167 cites W2028546276 @default.
• W4381122167 cites W2035833975 @default.
• W4381122167 cites W2039114029 @default.
• W4381122167 cites W2051055551 @default.
• W4381122167 cites W2051513829 @default.
• W4381122167 cites W2054110130 @default.
• W4381122167 cites W2054553973 @default.
• W4381122167 cites W2060343069 @default.
• W4381122167 cites W2063042123 @default.
• W4381122167 cites W2066093115 @default.
• W4381122167 cites W2071696504 @default.
• W4381122167 cites W2073390876 @default.
• W4381122167 cites W2074661552 @default.
• W4381122167 cites W2076567183 @default.
• W4381122167 cites W2077035859 @default.
• W4381122167 cites W2077479824 @default.
• W4381122167 cites W2079485368 @default.
• W4381122167 cites W2082955757 @default.
• W4381122167 cites W2083663126 @default.
• W4381122167 cites W2084099920 @default.
• W4381122167 cites W2084952516 @default.
• W4381122167 cites W2085017336 @default.
• W4381122167 cites W2087381559 @default.
• W4381122167 cites W2091026347 @default.
• W4381122167 cites W2092898068 @default.
• W4381122167 cites W2094240884 @default.
• W4381122167 cites W2094853551 @default.
• W4381122167 cites W2103044571 @default.
• W4381122167 cites W2114841061 @default.
• W4381122167 cites W2128229230 @default.
• W4381122167 cites W2128751464 @default.
• W4381122167 cites W2135960371 @default.
• W4381122167 cites W2141852514 @default.
• W4381122167 cites W2152793856 @default.
• W4381122167 cites W2154072118 @default.
• W4381122167 cites W2154592820 @default.
• W4381122167 cites W2190597025 @default.
• W4381122167 cites W2198623424 @default.
• W4381122167 cites W2204673349 @default.
• W4381122167 cites W2208088507 @default.
• W4381122167 cites W2230531921 @default.
• W4381122167 cites W2252808113 @default.
• W4381122167 cites W2258821072 @default.
• W4381122167 cites W2263242339 @default.
• W4381122167 cites W2417836321 @default.
• W4381122167 cites W2516254780 @default.
• W4381122167 cites W2552413362 @default.
• W4381122167 cites W2572710398 @default.
• W4381122167 cites W2592572343 @default.
• W4381122167 cites W2595697715 @default.
• W4381122167 cites W2626877551 @default.
• W4381122167 cites W2735769265 @default.
• W4381122167 cites W2769917108 @default.
• W4381122167 cites W2770073096 @default.
• W4381122167 cites W2770253777 @default.
• W4381122167 cites W2793756496 @default.
• W4381122167 cites W2795360338 @default.
• W4381122167 cites W2796848104 @default.
• W4381122167 cites W2803060237 @default.
• W4381122167 cites W2892146033 @default.
• W4381122167 cites W2897641451 @default.
• W4381122167 cites W2912920302 @default.
• W4381122167 cites W2912925231 @default.
• W4381122167 cites W2914152013 @default.
• W4381122167 cites W2915784940 @default.
• W4381122167 cites W2945570217 @default.
• W4381122167 cites W2970816691 @default.
• W4381122167 cites W2980627504 @default.
• W4381122167 cites W2994172746 @default.
• W4381122167 cites W3006551612 @default.

• next