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• W4381125611 abstract "<h3>Introduction</h3> Liver cirrhosis is a substantial risk factor for hepatocellular carcinoma. Regular surveillance of patient with liver cirrhosis at six months intervals helps to detect early stage hepatocellular, which is potentially curable. Our aim was to assess and improve our compliance with international guidelines on HCC surveillance in liver cirrhosis patients. <h3>Methods</h3> A retrospect database of patients with underline diagnoses of primary or secondary cirrhosis admitted to Furness General Hospital over the period of two years (July 2019 to July 2021) was retrieved through the Lorenzo EPR. Our cohort included 215 patients. <h3>Date collection included</h3> Mean age of death and diagnosis of liver cirrhosis in our cohort. Mortality rate in our patients. First radiological evidence of liver cirrhosis. Number of scans (Us or CT) performed since diagnose. Number of alpha-fetoprotein done since initial diagnose of liver cirrhosis. Number of patients developed HCC. <h3>Results</h3> We excluded 74 patients due to technical issues in retrieving data or who had no radiological evidence of liver cirrhosis and thus our final cohort included 141 patients with 60% male (n=85) and 40% female (n=56). The median age of our cohort was 67 with 60% male (n=85) and 40% female (n=56). Mean age of diagnosis of liver cirrhosis and death in our cohort was 62 and 63 respectively. 10% (n=14) of patients developed HCC. One patient underwent successful liver transplantation. The mortality rate was 32% (n=46) and this rise to 60% in patients who developed HCC. 50% (n=71) of the cohort had completed >50% of recommended six monthly ultrasound and only 22% of the patients had >50% of six monthly AFP measurement. <i>Figure 1: Percentage of patient who completed more than 50% of recommended surveillance.</i> <h3>Conclusions</h3> From our audit it is evident that: • Mortality rate is high in liver cirrhosis patients and these increases significantly with HCC diagnosis. • Our compliance with established HCC surveillance recommendations for liver cirrhosis patients does not meet international guidelines. Furthermore, adherence to surveillance might improve patient’s survival. <h3>References</h3> Flemming JA, Yang JD, Vittinghoff E, Kim WR, Terault NA. Risk prediction of hepatocellular carcinoma in patients with cirrhosis: the ADRESS-HCC risk model. 2014;<b>120</b>(220):3485–93. Bruix J, Sherman M. Management of hepatocellular carcinoma: an update. <i>Hepatology</i> 2011;<b>53</b>(3):1022–2. Harrison P, Hogan BJ, Floros L, Davies E. Assessment and management of cirrhosis in people older than 16: summary of NICE guidance. <i>BMJ</i> 2016;<b>354</b>:i2580." @default.
• W4381125611 created "2023-06-19" @default.
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• W4381125611 date "2023-06-01" @default.
• W4381125611 modified "2023-10-06" @default.
• W4381125611 title "P43 Hepatocellular carcinoma surveillance in liver cirrhosis patient" @default.
• W4381125611 doi "https://doi.org/10.1136/gutjnl-2023-bsg.115" @default.
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