Matches in SemOpenAlex for { <https://semopenalex.org/work/W4381125663> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W4381125663 abstract "Abstract Funding Acknowledgements Type of funding sources: None. Background Severe aortic-stenosis (AS) is the guideline-based indication for aortic-valve-replacement (AVR) performance, which has markedly increased with transcatheter approaches, suggesting possible increasing AS incidence. However, reported secular trends of AS incidence remain contradictory, uncertain and lacking quantitative Doppler-Echocardiographic ascertainment. Thus, population-based trends in presentation, treatment and outcome are unknown. Methods All adults residents our County (MN,USA) diagnosed with incident (first-diagnosis) severe AS based on quantitative Doppler-Echocardiography (aortic-valve-area≤1cm2, aortic-valve-area-index≤0.6cm2/m2, mean-gradient≥40mmHg, peak-velocity≥4m/s, Doppler-velocity-index≤0.25) between 1997–2016, were accounted for and trends for incidence, presentation, treatment and outcome analysed. Results Incident severe-AS was diagnosed in 1069 community-residents over 20-years. Incidence-rate was 52.5[49.4–55.8] per 100.000 patient/year, slightly higher in male vs. female and was almost unchanged after age and sex adjustment for the US population 53.8[50.6–57.0] per-100000 residents/year. Over 20-years severe AS-incidence remained stable (p = 0.20) but absolute-burden of incident-cases markedly increased (p = 0.0004) due to population growth. Incidence-trend differed by sex, stable in men (incidence-rate-ratio 0.99, p = 0.72) but declining in women: (incidence-rate-ratio 0.93, p = 0.024). AS clinical-presentation, age, symptoms, comorbidity, ventricular size/function, valve-area-index, low-flow or low-ejection-fraction AS, remained stable. Over the study 20 years, AVR performance grew (1997–2001 to 2012–2016, at 3-month:14% to 21%, p = 0.02; at 1-year 19% to 33%,p<0.0001), and was more prompt (from 1.3[0.11–3.3]years in 1997–2001 to 0.48[0.15–2.11]years in 2013–2016, p = 0.001) but severe AS undertreatment remained prominent (>40%). Early-AVR (within 3-months) was associated with survival benefit (adjusted-hazard-ratio 0.55[0.42–0.71], p<0.0001) stable throughout the 20-years. Despite these improvements, overall mortality, 8.3% within 3-months, 17.8% within 1-year, 36% within 3-years, was swift, considerable and unabated (all p≥0.44) throughout the 20-year study. Conclusion Over 20 years, the population incidence of severe-AS remained stable with increased absolute case-burden purely related to population growth. Despite stable severe-AS presentation, AVR performance grew notably, but while declining, undertreatment remained substantial and disease-lethality did not decline. These findings have important population-health management implications." @default.
- W4381125663 created "2023-06-19" @default.
- W4381125663 creator A5000497087 @default.
- W4381125663 creator A5021276165 @default.
- W4381125663 creator A5035051569 @default.
- W4381125663 creator A5039047362 @default.
- W4381125663 creator A5056361387 @default.
- W4381125663 creator A5058058382 @default.
- W4381125663 creator A5060848081 @default.
- W4381125663 creator A5060916411 @default.
- W4381125663 creator A5077287134 @default.
- W4381125663 creator A5078424130 @default.
- W4381125663 creator A5078443392 @default.
- W4381125663 creator A5083715084 @default.
- W4381125663 date "2023-06-01" @default.
- W4381125663 modified "2023-10-18" @default.
- W4381125663 title "Incidence trends and management of severe aortic valve stenosis in the community over 20 years of practice" @default.
- W4381125663 doi "https://doi.org/10.1093/ehjci/jead119.148" @default.
- W4381125663 hasPublicationYear "2023" @default.
- W4381125663 type Work @default.
- W4381125663 citedByCount "0" @default.
- W4381125663 crossrefType "journal-article" @default.
- W4381125663 hasAuthorship W4381125663A5000497087 @default.
- W4381125663 hasAuthorship W4381125663A5021276165 @default.
- W4381125663 hasAuthorship W4381125663A5035051569 @default.
- W4381125663 hasAuthorship W4381125663A5039047362 @default.
- W4381125663 hasAuthorship W4381125663A5056361387 @default.
- W4381125663 hasAuthorship W4381125663A5058058382 @default.
- W4381125663 hasAuthorship W4381125663A5060848081 @default.
- W4381125663 hasAuthorship W4381125663A5060916411 @default.
- W4381125663 hasAuthorship W4381125663A5077287134 @default.
- W4381125663 hasAuthorship W4381125663A5078424130 @default.
- W4381125663 hasAuthorship W4381125663A5078443392 @default.
- W4381125663 hasAuthorship W4381125663A5083715084 @default.
- W4381125663 hasBestOaLocation W43811256631 @default.
- W4381125663 hasConcept C120665830 @default.
- W4381125663 hasConcept C121332964 @default.
- W4381125663 hasConcept C126322002 @default.
- W4381125663 hasConcept C144024400 @default.
- W4381125663 hasConcept C149923435 @default.
- W4381125663 hasConcept C164705383 @default.
- W4381125663 hasConcept C167704817 @default.
- W4381125663 hasConcept C2776570981 @default.
- W4381125663 hasConcept C2778198053 @default.
- W4381125663 hasConcept C2780007028 @default.
- W4381125663 hasConcept C2780714102 @default.
- W4381125663 hasConcept C2908647359 @default.
- W4381125663 hasConcept C44249647 @default.
- W4381125663 hasConcept C61511704 @default.
- W4381125663 hasConcept C71924100 @default.
- W4381125663 hasConcept C78085059 @default.
- W4381125663 hasConcept C99454951 @default.
- W4381125663 hasConceptScore W4381125663C120665830 @default.
- W4381125663 hasConceptScore W4381125663C121332964 @default.
- W4381125663 hasConceptScore W4381125663C126322002 @default.
- W4381125663 hasConceptScore W4381125663C144024400 @default.
- W4381125663 hasConceptScore W4381125663C149923435 @default.
- W4381125663 hasConceptScore W4381125663C164705383 @default.
- W4381125663 hasConceptScore W4381125663C167704817 @default.
- W4381125663 hasConceptScore W4381125663C2776570981 @default.
- W4381125663 hasConceptScore W4381125663C2778198053 @default.
- W4381125663 hasConceptScore W4381125663C2780007028 @default.
- W4381125663 hasConceptScore W4381125663C2780714102 @default.
- W4381125663 hasConceptScore W4381125663C2908647359 @default.
- W4381125663 hasConceptScore W4381125663C44249647 @default.
- W4381125663 hasConceptScore W4381125663C61511704 @default.
- W4381125663 hasConceptScore W4381125663C71924100 @default.
- W4381125663 hasConceptScore W4381125663C78085059 @default.
- W4381125663 hasConceptScore W4381125663C99454951 @default.
- W4381125663 hasIssue "Supplement_1" @default.
- W4381125663 hasLocation W43811256631 @default.
- W4381125663 hasOpenAccess W4381125663 @default.
- W4381125663 hasPrimaryLocation W43811256631 @default.
- W4381125663 hasRelatedWork W1974042200 @default.
- W4381125663 hasRelatedWork W1978184204 @default.
- W4381125663 hasRelatedWork W2035507842 @default.
- W4381125663 hasRelatedWork W2394784933 @default.
- W4381125663 hasRelatedWork W2533259511 @default.
- W4381125663 hasRelatedWork W2741320683 @default.
- W4381125663 hasRelatedWork W2920644863 @default.
- W4381125663 hasRelatedWork W3091489670 @default.
- W4381125663 hasRelatedWork W3126586449 @default.
- W4381125663 hasRelatedWork W4210664585 @default.
- W4381125663 hasVolume "24" @default.
- W4381125663 isParatext "false" @default.
- W4381125663 isRetracted "false" @default.
- W4381125663 workType "article" @default.