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- W4381158085 abstract "Tetrakis(4-aminophenyl)porphyrin (1) and tetrakis(4-acetamidophenyl)porphyrin (2) were dissolved in water with the incorporation of a polysaccharide (λ-carrageenan (CGN)) as a water-solubilizing agent. Although the photodynamic activity of the CGN-2 complex was considerably lower than that of the CGN-1 complex, the selectivity index (SI; IC50 in a normal cell/IC50 in a cancer cell) of the CGN-2 complex was considerably higher than that of the CGN-1 complex. This is because the photodynamic activity of the CGN-2 complex was significantly affected by the intracellular uptakes by the normal and cancer cells. During in vivo experiments, the CGN-2 complex inhibited tumor growth under light irradiation with high blood retention compared with the CGN-1 complex and Photofrin, which exhibited lower blood retention. This study showed that the photodynamic activity and SI are influenced by substituent groups of arene in the meso-positions of porphyrin analogs." @default.
- W4381158085 created "2023-06-20" @default.
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- W4381158085 date "2023-07-27" @default.
- W4381158085 modified "2023-09-26" @default.
- W4381158085 title "Selective Photodynamic Activity of Tetrakis(4‐aminophenyl)porphyrins with and without Acetyl Protecting Groups on Cancer and Normal Cells" @default.
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- W4381158085 doi "https://doi.org/10.1002/chem.202301385" @default.
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