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- W4381158354 abstract "Introduction Hereditary angioedema (HAE) is characterized by recurrent subcutaneously and/or submucosally localized edematous swellings. The first symptoms often appear in childhood, and they may become more frequent and severe in puberty. Since the appearance of HAE attacks is unpredictable regarding the localization and the frequency, the attacks put a significant burden on the patients and crucially impacts their quality of life.Areas covered This review article analyzes the safety data acquired from the clinical trials conducted with the currently available medicinal products for the prophylactic treatment of hereditary angioedema due to C1 inhibitor deficiency and the safety data of observatory studies based on clinical practice. A review of the published literature was conducted using the PubMed database, clinical trials from ClinicalTrials.gov, and abstracts published at scientific conferences.Expert opinion The currently available therapeutic products have a good safety and efficiency profile and the international guidelines recommend them as first-line treatments. The choice should be made based on the evaluation of the availability and the preference of the patient." @default.
- W4381158354 created "2023-06-20" @default.
- W4381158354 creator A5078959215 @default.
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- W4381158354 date "2023-06-21" @default.
- W4381158354 modified "2023-10-16" @default.
- W4381158354 title "A safety review of prophylaxis drugs for adolescent patients with hereditary angioedema" @default.
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- W4381158354 doi "https://doi.org/10.1080/14740338.2023.2226861" @default.
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