Matches in SemOpenAlex for { <https://semopenalex.org/work/W4381161869> ?p ?o ?g. }
- W4381161869 endingPage "9964" @default.
- W4381161869 startingPage "9955" @default.
- W4381161869 abstract "Extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae has caused a global pandemic with high prevalence in livestock and poultry, which could disseminate into the environment and humans. To curb this risk, heat-based harmless treatment of livestock waste was carried out. However, some risks of the bacterial persistence have not been thoroughly assessed. This study demonstrated that antibiotic-resistant bacteria (ARB) could survive at 55 °C through dormancy, and simultaneously transformable extracellular antibiotic resistance genes (eARGs) would be released. The ESBL-producing pathogenic Escherichia coli CM1 from chicken manure could enter a dormant state at 55 °C and reactivate at 37 °C. Dormant CM1 had stronger β-lactam resistance, which was associated with high expression of β-lactamase genes and low expression of outer membrane porin genes. Resuscitated CM1 maintained its virulence expression and multidrug resistance and even had stronger cephalosporin resistance, which might be due to the ultra-low expression of the porin genes. Besides, heat at 55 °C promoted the release of eARGs, some of which possessed a certain nuclease stability and heat persistence, and even maintained their transformability to an Acinetobacter baylyi strain. Therefore, dormant multidrug-resistant pathogens from livestock waste will still pose a direct health risk to humans, while the resuscitation of dormant ARB and the transformation of released eARGs will jointly promote the proliferation of ARGs and the spread of antibiotic resistance." @default.
- W4381161869 created "2023-06-20" @default.
- W4381161869 creator A5024969519 @default.
- W4381161869 creator A5026694879 @default.
- W4381161869 creator A5027397220 @default.
- W4381161869 creator A5030850216 @default.
- W4381161869 creator A5047012082 @default.
- W4381161869 creator A5050829718 @default.
- W4381161869 creator A5054745855 @default.
- W4381161869 creator A5067201270 @default.
- W4381161869 creator A5067900039 @default.
- W4381161869 creator A5070787458 @default.
- W4381161869 creator A5091621841 @default.
- W4381161869 date "2023-06-19" @default.
- W4381161869 modified "2023-10-14" @default.
- W4381161869 title "Neglected Drivers of Antibiotic Resistance: Survival of Extended-Spectrum β-Lactamase-Producing Pathogenic <i>Escherichia coli</i> from Livestock Waste through Dormancy and Release of Transformable Extracellular Antibiotic Resistance Genes under Heat Treatment" @default.
- W4381161869 cites W1168996118 @default.
- W4381161869 cites W1779577705 @default.
- W4381161869 cites W1989712698 @default.
- W4381161869 cites W1993812350 @default.
- W4381161869 cites W2010907801 @default.
- W4381161869 cites W2020087100 @default.
- W4381161869 cites W2047223554 @default.
- W4381161869 cites W2048818420 @default.
- W4381161869 cites W2061911055 @default.
- W4381161869 cites W2064828535 @default.
- W4381161869 cites W2066384065 @default.
- W4381161869 cites W2069835720 @default.
- W4381161869 cites W2094936149 @default.
- W4381161869 cites W2099670883 @default.
- W4381161869 cites W2113758313 @default.
- W4381161869 cites W2120061656 @default.
- W4381161869 cites W2129944678 @default.
- W4381161869 cites W2132771466 @default.
- W4381161869 cites W2144729818 @default.
- W4381161869 cites W2153899497 @default.
- W4381161869 cites W2155664691 @default.
- W4381161869 cites W2156226538 @default.
- W4381161869 cites W2157428903 @default.
- W4381161869 cites W2165202736 @default.
- W4381161869 cites W2203081581 @default.
- W4381161869 cites W2246717355 @default.
- W4381161869 cites W2298538712 @default.
- W4381161869 cites W2327034209 @default.
- W4381161869 cites W2345859823 @default.
- W4381161869 cites W2425052233 @default.
- W4381161869 cites W2586590237 @default.
- W4381161869 cites W2721522249 @default.
- W4381161869 cites W2769809746 @default.
- W4381161869 cites W2772068663 @default.
- W4381161869 cites W2792174858 @default.
- W4381161869 cites W2793812194 @default.
- W4381161869 cites W2901673575 @default.
- W4381161869 cites W2915025759 @default.
- W4381161869 cites W2919510638 @default.
- W4381161869 cites W2965151145 @default.
- W4381161869 cites W2972260587 @default.
- W4381161869 cites W2982854690 @default.
- W4381161869 cites W2999274107 @default.
- W4381161869 cites W3000800775 @default.
- W4381161869 cites W3004316269 @default.
- W4381161869 cites W3008985227 @default.
- W4381161869 cites W3023525987 @default.
- W4381161869 cites W3025403080 @default.
- W4381161869 cites W3036552328 @default.
- W4381161869 cites W3048423238 @default.
- W4381161869 cites W3048450686 @default.
- W4381161869 cites W3091882470 @default.
- W4381161869 cites W3119617992 @default.
- W4381161869 cites W3122341166 @default.
- W4381161869 cites W3127597818 @default.
- W4381161869 cites W3153181198 @default.
- W4381161869 cites W3155732227 @default.
- W4381161869 cites W3166750842 @default.
- W4381161869 cites W3168062903 @default.
- W4381161869 cites W3170133581 @default.
- W4381161869 cites W3181080380 @default.
- W4381161869 cites W3215778832 @default.
- W4381161869 cites W4292513457 @default.
- W4381161869 cites W4318312799 @default.
- W4381161869 doi "https://doi.org/10.1021/acs.est.3c02377" @default.
- W4381161869 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37336722" @default.
- W4381161869 hasPublicationYear "2023" @default.
- W4381161869 type Work @default.
- W4381161869 citedByCount "0" @default.
- W4381161869 crossrefType "journal-article" @default.
- W4381161869 hasAuthorship W4381161869A5024969519 @default.
- W4381161869 hasAuthorship W4381161869A5026694879 @default.
- W4381161869 hasAuthorship W4381161869A5027397220 @default.
- W4381161869 hasAuthorship W4381161869A5030850216 @default.
- W4381161869 hasAuthorship W4381161869A5047012082 @default.
- W4381161869 hasAuthorship W4381161869A5050829718 @default.
- W4381161869 hasAuthorship W4381161869A5054745855 @default.
- W4381161869 hasAuthorship W4381161869A5067201270 @default.
- W4381161869 hasAuthorship W4381161869A5067900039 @default.
- W4381161869 hasAuthorship W4381161869A5070787458 @default.
- W4381161869 hasAuthorship W4381161869A5091621841 @default.
- W4381161869 hasConcept C104317684 @default.