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• W4381166115 abstract "A new library of 1,2,3-triazole linked isoflavone derivatives (9a-j) were synthesized and their structures were confirmed by 1HNMR, 13CNMR and mass spectral data. Further, the preliminary anticancer activities of compounds were evaluated against human prostate cancer (PC3 and DU-145), lung cancer (A549) and breast cancer (MCF-7) cell lines by using of MTT assay. Most of the tested compounds displayed good anticancer activity to compared with etoposide. Among the tested compounds, five compounds 9a, 9b, 9c, 9d and 9j possessed more potent activity than etoposide. In addition, Docking studies were also done on these compounds to probe the possible binding site interactions which corroborated well with the in vitro results." @default.
• W4381166115 created "2023-06-20" @default.
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• W4381166115 date "2023-06-18" @default.
• W4381166115 modified "2023-10-14" @default.
• W4381166115 title "Design and Synthesis of 1,2,3-Triazole Incorporated Isoflavone Derivatives as Anticancer Agents" @default.
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• W4381166115 doi "https://doi.org/10.1080/10406638.2023.2220863" @default.
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