Matches in SemOpenAlex for { <https://semopenalex.org/work/W4381187103> ?p ?o ?g. }
- W4381187103 endingPage "2701" @default.
- W4381187103 startingPage "2681" @default.
- W4381187103 abstract "Virus-induced lung injury is associated with loss of pulmonary epithelial-endothelial tight junction integrity. While the alveolar-capillary membrane may be an indirect target of injury, viruses may interact directly and/or indirectly with miRs to augment their replication potential and evade the host antiviral defense system. Here, we expose how the influenza virus (H1N1) capitalizes on host-derived interferon-induced, microRNA (miR)-193b-5p to target occludin and compromise antiviral defenses. Lung biopsies from patients infected with H1N1 revealed increased miR-193b-5p levels, marked reduction in occludin protein, and disruption of the alveolar-capillary barrier. In C57BL/6 mice, the expression of miR-193b-5p increased, and occludin decreased, 5-6 days post-infection with influenza (PR8). Inhibition of miR-193b-5p in primary human bronchial, pulmonary microvascular, and nasal epithelial cells enhanced antiviral responses. miR-193b-deficient mice were resistant to PR8. Knockdown of occludin, both in vitro and in vivo, and overexpression of miR-193b-5p reconstituted susceptibility to viral infection. miR-193b-5p inhibitor mitigated loss of occludin, improved viral clearance, reduced lung edema, and augmented survival in infected mice. Our results elucidate how the innate immune system may be exploited by the influenza virus and how strategies that prevent loss of occludin and preserve tight junction function may limit susceptibility to virus-induced lung injury." @default.
- W4381187103 created "2023-06-20" @default.
- W4381187103 creator A5002720973 @default.
- W4381187103 creator A5015849026 @default.
- W4381187103 creator A5015971960 @default.
- W4381187103 creator A5020781519 @default.
- W4381187103 creator A5021283763 @default.
- W4381187103 creator A5022205685 @default.
- W4381187103 creator A5024943259 @default.
- W4381187103 creator A5025146683 @default.
- W4381187103 creator A5026371597 @default.
- W4381187103 creator A5035096656 @default.
- W4381187103 creator A5042386818 @default.
- W4381187103 creator A5046685448 @default.
- W4381187103 creator A5047550947 @default.
- W4381187103 creator A5050278072 @default.
- W4381187103 creator A5053156433 @default.
- W4381187103 creator A5061450499 @default.
- W4381187103 creator A5065175470 @default.
- W4381187103 creator A5069291770 @default.
- W4381187103 creator A5070604004 @default.
- W4381187103 creator A5073885212 @default.
- W4381187103 creator A5080593288 @default.
- W4381187103 creator A5087186890 @default.
- W4381187103 creator A5091313128 @default.
- W4381187103 creator A5092201787 @default.
- W4381187103 date "2023-09-01" @default.
- W4381187103 modified "2023-10-17" @default.
- W4381187103 title "Preventing occludin tight-junction disruption via inhibition of microRNA-193b-5p attenuates viral load and influenza-induced lung injury" @default.
- W4381187103 cites W1600022398 @default.
- W4381187103 cites W1683082659 @default.
- W4381187103 cites W1884525829 @default.
- W4381187103 cites W1906516115 @default.
- W4381187103 cites W1910286204 @default.
- W4381187103 cites W1937948046 @default.
- W4381187103 cites W1970338528 @default.
- W4381187103 cites W1971273590 @default.
- W4381187103 cites W1985312853 @default.
- W4381187103 cites W1997334236 @default.
- W4381187103 cites W1998810251 @default.
- W4381187103 cites W1999970685 @default.
- W4381187103 cites W2003988251 @default.
- W4381187103 cites W2025491143 @default.
- W4381187103 cites W2026930115 @default.
- W4381187103 cites W2028586825 @default.
- W4381187103 cites W2030435075 @default.
- W4381187103 cites W2034693792 @default.
- W4381187103 cites W2041847917 @default.
- W4381187103 cites W2045147732 @default.
- W4381187103 cites W2048648611 @default.
- W4381187103 cites W2067349015 @default.
- W4381187103 cites W2068353535 @default.
- W4381187103 cites W2072292894 @default.
- W4381187103 cites W2076198632 @default.
- W4381187103 cites W2086648451 @default.
- W4381187103 cites W2093588907 @default.
- W4381187103 cites W2102933822 @default.
- W4381187103 cites W2105396871 @default.
- W4381187103 cites W2105415231 @default.
- W4381187103 cites W2111994809 @default.
- W4381187103 cites W2120442500 @default.
- W4381187103 cites W2139476818 @default.
- W4381187103 cites W2141659272 @default.
- W4381187103 cites W2149299006 @default.
- W4381187103 cites W2152810785 @default.
- W4381187103 cites W2154283725 @default.
- W4381187103 cites W2155957079 @default.
- W4381187103 cites W2161138634 @default.
- W4381187103 cites W2161693225 @default.
- W4381187103 cites W2163830368 @default.
- W4381187103 cites W2169186082 @default.
- W4381187103 cites W2169865372 @default.
- W4381187103 cites W2170319572 @default.
- W4381187103 cites W2256756668 @default.
- W4381187103 cites W2271074187 @default.
- W4381187103 cites W2291675941 @default.
- W4381187103 cites W2341508496 @default.
- W4381187103 cites W2344940604 @default.
- W4381187103 cites W2407212762 @default.
- W4381187103 cites W2465742979 @default.
- W4381187103 cites W2523101278 @default.
- W4381187103 cites W2578005846 @default.
- W4381187103 cites W2592473983 @default.
- W4381187103 cites W2600400434 @default.
- W4381187103 cites W2613738073 @default.
- W4381187103 cites W2615531805 @default.
- W4381187103 cites W2731326819 @default.
- W4381187103 cites W2735170961 @default.
- W4381187103 cites W2765531046 @default.
- W4381187103 cites W2766944361 @default.
- W4381187103 cites W2786480557 @default.
- W4381187103 cites W2791913107 @default.
- W4381187103 cites W2794921255 @default.
- W4381187103 cites W2803865464 @default.
- W4381187103 cites W2806388412 @default.
- W4381187103 cites W2903444830 @default.
- W4381187103 cites W2906500641 @default.
- W4381187103 cites W2910552487 @default.