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- W4381188730 abstract "PurposeThis study aimed to clarify the effect of 1-year oral treatment with 9-cis-β-carotene-rich alga Dunaliella Bardawil (Dunaliella supplementation) using full-field electroretinography (ERG) in patients with RDH5-related fundus albipunctatus (FAP).DesignProspective interventional case seriesParticipantsThe study included 12 patients (23 eyes) with RDH5-related FAP.MethodsTwelve patients (23 eyes) with RDH5-related FAP received Dunaliella supplementation (total daily dose of β-carotene was 74.0 mg, comprising 28.4 mg 9-cis-β-carotene and 45.6 mg all-trans-β-carotene at a ratio of 1:1.6) for 1 year and underwent ophthalmic examinations, including full-field ERG at baseline, 3 months, and 1 year after the initial treatment.Main Outcome MeasuresThe main outcome was changes in the amplitudes of responses of full-field ERG before and after treatment. A linear mixed-effects model was used to evaluate the adjusted mean difference between the amplitude of each response pre-treatment and post-treatment.ResultsProlonged dark adapted (DA) responses at 3 months revealed a significant impairment in the b-wave of DA 0.01 (adjusted mean difference; −34.7, 95% CI; −66.8 to −2.73, p = 0.041) and a-wave of DA 3.0 (−29.0, 95% CI; −50.6 to −7.41, p = 0.013) and DA10.0 (−40.4, 95% CI; −67.8 to −13.0, p = 0.007), which were also observed at 1 year. Additionally, prolonged DA and light adapted (LA) responses revealed statistically significant impairment at 1 year in the b-wave of DA 3.0 (−43.8, 95% CI; −82.9 to −4.78, p = 0.035), DA 10.0 (−59.7, 95% CI; −101.8 to −17.61, p = 0.009), LA 3.0 (−7.31, 95% CI; −13.6 to −1.04, p = 0.029), and in LA 3.0 flicker (−7.53, 95% CI; −12.7 to −2.34, p = 0.007).ConclusionsOur study results suggest that Dunaliella supplementation comprising low levels of 9-cis-β-carotene compared with those reported in a previous study (1:1 ratio) adversely affects ERG amplitudes in patients with RDH5-related FAP." @default.
- W4381188730 created "2023-06-20" @default.
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- W4381188730 date "2023-10-01" @default.
- W4381188730 modified "2023-10-16" @default.
- W4381188730 title "One-Year Outcomes of Oral Treatment With Alga Capsules Containing Low Levels of 9-cis-β-Carotene in RDH5-Related Fundus Albipunctatus" @default.
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- W4381188730 doi "https://doi.org/10.1016/j.ajo.2023.06.013" @default.
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