Matches in SemOpenAlex for { <https://semopenalex.org/work/W4381189638> ?p ?o ?g. }
- W4381189638 endingPage "30" @default.
- W4381189638 startingPage "30" @default.
- W4381189638 abstract "Tissue stiffening and alterations in retinal blood flow have both been suggested as causative mechanisms of glaucomatous damage. We tested the hypothesis that retinal blood vessels also stiffen, using laser speckle flowgraphy (LSFG) to characterize vascular resistance.In the longitudinal Portland Progression Project, 231 eyes of 124 subjects received LSFG scans of the optic nerve head (ONH) and automated perimetry every 6 months for six visits. Eyes were classified as either glaucoma suspect or glaucoma eyes based on the presence of functional loss on the first visit. Vascular resistance was quantified using the mean values of several instrument-defined parameterizations of the pulsatile waveform measured by LSFG, either in major vessels within the ONH (serving the retina) or in capillaries within ONH tissue, and age-adjusted using a separate group of 127 healthy eyes of 63 individuals. Parameters were compared against the severity and rate of change of functional loss using mean deviation (MD) over the six visits, within the two groups.Among 118 glaucoma suspect eyes (average MD, -0.4 dB; rate, -0.45 dB/y), higher vascular resistance was related to faster functional loss, but not current severity of loss. Parameters measured in major vessels were stronger predictors of rate than parameters measured in tissue. Among 113 glaucoma eyes (average MD, -4.3 dB; rate, -0.53 dB/y), higher vascular resistance was related to more severe current loss but not rate of loss.Higher retinal vascular resistance and, by likely implication, stiffer retinal vessels were associated with more rapid functional loss in eyes without significant existing loss at baseline." @default.
- W4381189638 created "2023-06-20" @default.
- W4381189638 creator A5032073359 @default.
- W4381189638 creator A5033957225 @default.
- W4381189638 creator A5073992146 @default.
- W4381189638 date "2023-06-19" @default.
- W4381189638 modified "2023-10-05" @default.
- W4381189638 title "Retinal Vessel Pulsatile Characteristics Associated With Vascular Stiffness Can Predict the Rate of Functional Progression in Glaucoma Suspects" @default.
- W4381189638 cites W1542887848 @default.
- W4381189638 cites W1576560915 @default.
- W4381189638 cites W1784721671 @default.
- W4381189638 cites W1968597772 @default.
- W4381189638 cites W1980150361 @default.
- W4381189638 cites W1982483134 @default.
- W4381189638 cites W1982537788 @default.
- W4381189638 cites W1983292111 @default.
- W4381189638 cites W2001197332 @default.
- W4381189638 cites W2004415062 @default.
- W4381189638 cites W2005657614 @default.
- W4381189638 cites W2006721173 @default.
- W4381189638 cites W2008867186 @default.
- W4381189638 cites W2011481648 @default.
- W4381189638 cites W2015371501 @default.
- W4381189638 cites W2016938633 @default.
- W4381189638 cites W2018784944 @default.
- W4381189638 cites W2021199278 @default.
- W4381189638 cites W2024376451 @default.
- W4381189638 cites W2029358406 @default.
- W4381189638 cites W2032930138 @default.
- W4381189638 cites W2038047187 @default.
- W4381189638 cites W2048830691 @default.
- W4381189638 cites W2060287042 @default.
- W4381189638 cites W2065969837 @default.
- W4381189638 cites W2077037485 @default.
- W4381189638 cites W2077553303 @default.
- W4381189638 cites W2080783569 @default.
- W4381189638 cites W2081437097 @default.
- W4381189638 cites W2085343878 @default.
- W4381189638 cites W2085922707 @default.
- W4381189638 cites W2087256371 @default.
- W4381189638 cites W2092433290 @default.
- W4381189638 cites W2096096036 @default.
- W4381189638 cites W2143189496 @default.
- W4381189638 cites W2147093603 @default.
- W4381189638 cites W2149860264 @default.
- W4381189638 cites W2156460824 @default.
- W4381189638 cites W2157940561 @default.
- W4381189638 cites W2161586203 @default.
- W4381189638 cites W2171240327 @default.
- W4381189638 cites W2268705759 @default.
- W4381189638 cites W2286190851 @default.
- W4381189638 cites W2289507764 @default.
- W4381189638 cites W2347164850 @default.
- W4381189638 cites W2400270750 @default.
- W4381189638 cites W2464557714 @default.
- W4381189638 cites W2486178676 @default.
- W4381189638 cites W2495298820 @default.
- W4381189638 cites W2530137706 @default.
- W4381189638 cites W2562274154 @default.
- W4381189638 cites W2592956410 @default.
- W4381189638 cites W2733018469 @default.
- W4381189638 cites W2733736540 @default.
- W4381189638 cites W2734838012 @default.
- W4381189638 cites W2751445665 @default.
- W4381189638 cites W2761678232 @default.
- W4381189638 cites W2804005100 @default.
- W4381189638 cites W2886715687 @default.
- W4381189638 cites W2963148820 @default.
- W4381189638 cites W3043041115 @default.
- W4381189638 cites W3092544125 @default.
- W4381189638 cites W3119054855 @default.
- W4381189638 cites W3125289729 @default.
- W4381189638 cites W3184743690 @default.
- W4381189638 cites W3186667595 @default.
- W4381189638 cites W3188252071 @default.
- W4381189638 cites W3204348275 @default.
- W4381189638 cites W3207399171 @default.
- W4381189638 cites W4210914315 @default.
- W4381189638 cites W4211261225 @default.
- W4381189638 cites W4214697793 @default.
- W4381189638 cites W4243779942 @default.
- W4381189638 cites W4256682987 @default.
- W4381189638 cites W4306152224 @default.
- W4381189638 doi "https://doi.org/10.1167/iovs.64.7.30" @default.
- W4381189638 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37335567" @default.
- W4381189638 hasPublicationYear "2023" @default.
- W4381189638 type Work @default.
- W4381189638 citedByCount "2" @default.
- W4381189638 countsByYear W43811896382023 @default.
- W4381189638 crossrefType "journal-article" @default.
- W4381189638 hasAuthorship W4381189638A5032073359 @default.
- W4381189638 hasAuthorship W4381189638A5033957225 @default.
- W4381189638 hasAuthorship W4381189638A5073992146 @default.
- W4381189638 hasBestOaLocation W43811896381 @default.
- W4381189638 hasConcept C118487528 @default.
- W4381189638 hasConcept C169760540 @default.
- W4381189638 hasConcept C2777093970 @default.
- W4381189638 hasConcept C2778527774 @default.