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• W4381190094 abstract "BackgroundThe global COVID-19 pandemic disproportionately affected certain populations and its management differed between countries. This national study describes characteristics and outcomes of COVID-19 in patients with cancer in Australia.MethodsWe performed a multicentre cohort study of patients with cancer and COVID-19 from March 2020 to April 2022. Data were analysed to determine varying characteristics between cancer types and changes in outcomes over time. Multivariable analysis was performed to determine risk factors associated with oxygen requirement.Findings620 patients with cancer from 15 hospitals had confirmed COVID-19. There were 314/620 (50.6%) male patients, median age 63.5 years (IQR 50–72) and majority had solid organ tumours (392/620, 63.2%). The rate of COVID-19 vaccination (≥1 dose) was 73.4% (455/620). Time from symptom onset to diagnosis was median 1 day (IQR 0–3), patients with haematological malignancy had a longer duration of test positivity. Over the study period, there was a significant decline in COVID-19 severity. Risk factors associated with oxygen requirement included male sex (OR 2.34, 95% CI 1.30–4.20, p = 0.004), age (OR 1.03, 95% CI 1.01–1.06, p = 0.005); not receiving early outpatient therapy (OR 2.78, 95% CI 1.41–5.50, p = 0.003). Diagnosis during the omicron wave was associated with lower odds of oxygen requirement (OR 0.24, 95% CI 0.13–0.43, p < 0.0001).InterpretationOutcomes from COVID-19 in patients with cancer in Australia over the pandemic have improved, potentially related to changing viral strain and outpatient therapies.FundingThis study was supported by research funding from MSD." @default.
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• W4381190094 date "2023-09-01" @default.
• W4381190094 modified "2023-10-16" @default.
• W4381190094 title "COVID-19 infection among patients with cancer in Australia from 2020 to 2022: a national multicentre cohort study" @default.
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• W4381190094 doi "https://doi.org/10.1016/j.lanwpc.2023.100824" @default.
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