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- W4381192116 abstract "Jellyfish and sea anemones fire single-use, venom-covered barbs to immobilize prey or predators. We previously showed that the anemone Nematostella vectensis uses a specialized voltage-gated calcium (Ca V ) channel to trigger stinging in response to synergistic prey-derived chemicals and touch (Weir et al., 2020). Here we use experiments and theory to find that stinging behavior is suited to distinct ecological niches. We find that the burrowing anemone Nematostella uses uniquely strong Ca V inactivation for precise control of predatory stinging. In contrast, the related anemone Exaiptasia diaphana inhabits exposed environments to support photosynthetic endosymbionts. Consistent with its niche, Exaiptasia indiscriminately stings for defense and expresses a Ca V splice variant that confers weak inactivation. Chimeric analyses reveal that Ca V subunit adaptations regulate inactivation, suggesting an evolutionary tuning mechanism for stinging behavior. These findings demonstrate how functional specialization of ion channel structure contributes to distinct organismal behavior." @default.
- W4381192116 created "2023-06-20" @default.
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- W4381192116 date "2023-06-16" @default.
- W4381192116 modified "2023-10-16" @default.
- W4381192116 title "Molecular tuning of sea anemone stinging" @default.
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- W4381192116 doi "https://doi.org/10.1101/2023.06.15.545144" @default.
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