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- W4381192783 abstract "In current nanopore-based label-free single-molecule sensing technologies, stochastic processes influence the selection of translocating molecule, translocation rate and translocation velocity. As a result, single-molecule translocations are challenging to control both spatially and temporally. Here we present a method using a glass nanopore mounted on a three-dimensional nanopositioner to spatially select molecules, deterministically tethered on a glass surface, for controlled translocations. By controlling the distance between the nanopore and glass surface, we can actively select the region of interest on the molecule and scan it a controlled number of times and at a controlled velocity. Decreasing the velocity and averaging thousands of consecutive readings of the same molecule increases the signal-to-noise ratio by two orders of magnitude compared with free translocations. We demonstrate the method's versatility by assessing DNA-protein complexes, DNA rulers and DNA gaps, achieving down to single-nucleotide gap detection." @default.
- W4381192783 created "2023-06-20" @default.
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- W4381192783 date "2023-06-19" @default.
- W4381192783 modified "2023-10-10" @default.
- W4381192783 title "Spatially multiplexed single-molecule translocations through a nanopore at controlled speeds" @default.
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- W4381192783 doi "https://doi.org/10.1038/s41565-023-01412-4" @default.
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