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• W4381193983 startingPage "1462" @default.
• W4381193983 abstract "Cell proliferation is a central process in tissue development, homeostasis, and disease, yet how proliferation is regulated in the tissue context remains poorly understood. Here, we introduce a quantitative framework to elucidate how tissue growth dynamics regulate cell proliferation. Using MDCK epithelial monolayers, we show that a limiting rate of tissue expansion creates confinement that suppresses cell growth; however, this confinement does not directly affect the cell cycle. This leads to uncoupling between rates of cell growth and division in epithelia and, thereby, reduces cell volume. Division becomes arrested at a minimal cell volume, which is consistent across diverse epithelia in vivo. Here, the nucleus approaches the minimum volume capable of packaging the genome. Loss of cyclin D1-dependent cell-volume regulation results in an abnormally high nuclear-to-cytoplasmic volume ratio and DNA damage. Overall, we demonstrate how epithelial proliferation is regulated by the interplay between tissue confinement and cell-volume regulation." @default.
• W4381193983 created "2023-06-20" @default.
• W4381193983 creator A5005425034 @default.
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• W4381193983 creator A5057339113 @default.
• W4381193983 date "2023-08-01" @default.
• W4381193983 modified "2023-10-17" @default.
• W4381193983 title "Epithelial tissue confinement inhibits cell growth and leads to volume-reducing divisions" @default.
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• W4381193983 doi "https://doi.org/10.1016/j.devcel.2023.05.018" @default.
• W4381193983 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37339629" @default.
• W4381193983 hasPublicationYear "2023" @default.
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