Matches in SemOpenAlex for { <https://semopenalex.org/work/W4381198932> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W4381198932 endingPage "293" @default.
- W4381198932 startingPage "275" @default.
- W4381198932 abstract "Nucleophilic addition to amides has been recognized as a promising transformation for the total synthesis of polycyclic alkaloids. The reaction produces substituted amines from easily available amides while avoiding the unwanted high reactivities of amines and use of extra-protecting group manipulations. In this chapter, we introduce the development of two types of amide-selective nucleophilic addition reactions and their applications to total synthesis. The first topic is the total synthesis of gephyrotoxin based on the reductive allylation of an N-methoxylactam. The reaction takes place in the presence of a more electrophilic methyl ester by taking advantage of the N-methoxy group and the Schwartz reagent [Cp2ZrHCl]. The second topic is the unified total synthesis of stemoamide-type alkaloids by chemoselective assembly of five-membered rings. The most challenging step is an iridium-catalyzed reductive nucleophilic addition to a γ-lactam. A γ-lactone was installed to a γ-lactam carbonyl without affecting the γ-lactone found in tetracyclic protostemonamide, resulting in the total synthesis of pentacyclic protostemonines." @default.
- W4381198932 created "2023-06-20" @default.
- W4381198932 creator A5041967476 @default.
- W4381198932 date "2023-01-01" @default.
- W4381198932 modified "2023-10-16" @default.
- W4381198932 title "Nucleophilic Addition to Amides Toward Efficient Total Synthesis of Complex Alkaloids" @default.
- W4381198932 cites W1927002568 @default.
- W4381198932 cites W1968031346 @default.
- W4381198932 cites W1969038657 @default.
- W4381198932 cites W1974671081 @default.
- W4381198932 cites W1983088981 @default.
- W4381198932 cites W1985660545 @default.
- W4381198932 cites W1995166961 @default.
- W4381198932 cites W1995239569 @default.
- W4381198932 cites W1995478624 @default.
- W4381198932 cites W2000283975 @default.
- W4381198932 cites W2002156127 @default.
- W4381198932 cites W2012699129 @default.
- W4381198932 cites W2014555103 @default.
- W4381198932 cites W2033293993 @default.
- W4381198932 cites W2039802871 @default.
- W4381198932 cites W2041293826 @default.
- W4381198932 cites W2052895214 @default.
- W4381198932 cites W2062619822 @default.
- W4381198932 cites W2077019845 @default.
- W4381198932 cites W2103521857 @default.
- W4381198932 cites W2117746367 @default.
- W4381198932 cites W2122915454 @default.
- W4381198932 cites W2147210980 @default.
- W4381198932 cites W2159363333 @default.
- W4381198932 cites W2168315718 @default.
- W4381198932 cites W2516356348 @default.
- W4381198932 cites W2766301090 @default.
- W4381198932 cites W2770008684 @default.
- W4381198932 cites W2770972943 @default.
- W4381198932 cites W2801921577 @default.
- W4381198932 cites W2803111983 @default.
- W4381198932 cites W2803954802 @default.
- W4381198932 cites W2950984019 @default.
- W4381198932 cites W3044807851 @default.
- W4381198932 cites W3087551210 @default.
- W4381198932 cites W4253266882 @default.
- W4381198932 cites W874793669 @default.
- W4381198932 doi "https://doi.org/10.1007/978-981-99-1714-3_13" @default.
- W4381198932 hasPublicationYear "2023" @default.
- W4381198932 type Work @default.
- W4381198932 citedByCount "0" @default.
- W4381198932 crossrefType "book-chapter" @default.
- W4381198932 hasAuthorship W4381198932A5041967476 @default.
- W4381198932 hasConcept C161790260 @default.
- W4381198932 hasConcept C178790620 @default.
- W4381198932 hasConcept C178907741 @default.
- W4381198932 hasConcept C185592680 @default.
- W4381198932 hasConcept C20774148 @default.
- W4381198932 hasConcept C21951064 @default.
- W4381198932 hasConcept C2776131168 @default.
- W4381198932 hasConcept C2776612806 @default.
- W4381198932 hasConcept C2778439535 @default.
- W4381198932 hasConcept C35753019 @default.
- W4381198932 hasConcept C40875361 @default.
- W4381198932 hasConcept C50027330 @default.
- W4381198932 hasConcept C71240020 @default.
- W4381198932 hasConceptScore W4381198932C161790260 @default.
- W4381198932 hasConceptScore W4381198932C178790620 @default.
- W4381198932 hasConceptScore W4381198932C178907741 @default.
- W4381198932 hasConceptScore W4381198932C185592680 @default.
- W4381198932 hasConceptScore W4381198932C20774148 @default.
- W4381198932 hasConceptScore W4381198932C21951064 @default.
- W4381198932 hasConceptScore W4381198932C2776131168 @default.
- W4381198932 hasConceptScore W4381198932C2776612806 @default.
- W4381198932 hasConceptScore W4381198932C2778439535 @default.
- W4381198932 hasConceptScore W4381198932C35753019 @default.
- W4381198932 hasConceptScore W4381198932C40875361 @default.
- W4381198932 hasConceptScore W4381198932C50027330 @default.
- W4381198932 hasConceptScore W4381198932C71240020 @default.
- W4381198932 hasLocation W43811989321 @default.
- W4381198932 hasOpenAccess W4381198932 @default.
- W4381198932 hasPrimaryLocation W43811989321 @default.
- W4381198932 hasRelatedWork W1986121368 @default.
- W4381198932 hasRelatedWork W2103521857 @default.
- W4381198932 hasRelatedWork W2147616513 @default.
- W4381198932 hasRelatedWork W2770972943 @default.
- W4381198932 hasRelatedWork W2801921577 @default.
- W4381198932 hasRelatedWork W2949683147 @default.
- W4381198932 hasRelatedWork W2950826583 @default.
- W4381198932 hasRelatedWork W3212325711 @default.
- W4381198932 hasRelatedWork W4238413425 @default.
- W4381198932 hasRelatedWork W4292457930 @default.
- W4381198932 isParatext "false" @default.
- W4381198932 isRetracted "false" @default.
- W4381198932 workType "book-chapter" @default.