Matches in SemOpenAlex for { <https://semopenalex.org/work/W4381232531> ?p ?o ?g. }
- W4381232531 endingPage "318" @default.
- W4381232531 startingPage "281" @default.
- W4381232531 abstract "Tocophersolan (D-α-tocopheryl polyethylene glycol succinate or TPGS) is a non-ionic surfactant fabricated by esterifying Vitamin E succinate with polyethylene glycol. Owing to its amphipathic nature and unique physicochemical attributes, TPGS offers multiple advantages in drug delivery, such as improving solubility, permeability, and bioavailability as well as assisting in designing a range of vesicular, micellar, and novel multi-particulate drug formulations. Moreover, it possesses nutritional values and has been grouped as a safe excipient by US FDA and EMA for topical, parenteral, and nasal formulations. These unique attributes make TPGS more apt for the development of novel carriers for successful pulmonary drug delivery. The present chapter aims to summarize various TPGS-based pulmonary drug delivery systems. The introductory segment focuses on the pharmacotherapy of chronic respiratory disorders and the function of nutritional agents, i.e., TPGS in respiratory disease management. Subsequent section deals with physicochemical attributes and applications of TPGS in the pharmaceutical sector. The third section thoroughly describes the impact of TPGS-based biomaterials on aerosolization performance. The section also highlights the biological consequences after intratracheal administration of TPGS-based delivery systems and in vivo anticancer activity using a lung cancer-bearing animal model. The last piece of the chapter highlights the opportunities and challenges allied to TPGS-based delivery cargos. Briefly, TPGS-based multimodal therapeutic delivery platforms offer promising outcomes in respiratory disease management." @default.
- W4381232531 created "2023-06-20" @default.
- W4381232531 creator A5036438316 @default.
- W4381232531 creator A5044280510 @default.
- W4381232531 date "2023-01-01" @default.
- W4381232531 modified "2023-10-16" @default.
- W4381232531 title "TPGS Functionalized Carriers: An Emerging Approach for Pulmonary Drug Delivery" @default.
- W4381232531 cites W1609696403 @default.
- W4381232531 cites W1868973104 @default.
- W4381232531 cites W1970110601 @default.
- W4381232531 cites W1981055785 @default.
- W4381232531 cites W1982706858 @default.
- W4381232531 cites W1984659376 @default.
- W4381232531 cites W2018100288 @default.
- W4381232531 cites W2021531309 @default.
- W4381232531 cites W2029677759 @default.
- W4381232531 cites W2029765873 @default.
- W4381232531 cites W2029773366 @default.
- W4381232531 cites W2030105886 @default.
- W4381232531 cites W2037873691 @default.
- W4381232531 cites W2041255666 @default.
- W4381232531 cites W2049782114 @default.
- W4381232531 cites W2060265857 @default.
- W4381232531 cites W2060273830 @default.
- W4381232531 cites W2061215349 @default.
- W4381232531 cites W2069542630 @default.
- W4381232531 cites W2076906033 @default.
- W4381232531 cites W2083656439 @default.
- W4381232531 cites W2086624992 @default.
- W4381232531 cites W2088957067 @default.
- W4381232531 cites W2113676592 @default.
- W4381232531 cites W2131837055 @default.
- W4381232531 cites W2144442790 @default.
- W4381232531 cites W2162647379 @default.
- W4381232531 cites W2163326536 @default.
- W4381232531 cites W2166792549 @default.
- W4381232531 cites W2174185258 @default.
- W4381232531 cites W2182588764 @default.
- W4381232531 cites W2323579145 @default.
- W4381232531 cites W2464234613 @default.
- W4381232531 cites W2500141147 @default.
- W4381232531 cites W2507854494 @default.
- W4381232531 cites W2513488060 @default.
- W4381232531 cites W2517555830 @default.
- W4381232531 cites W2518163592 @default.
- W4381232531 cites W2530081471 @default.
- W4381232531 cites W2541281961 @default.
- W4381232531 cites W2549460479 @default.
- W4381232531 cites W2558871978 @default.
- W4381232531 cites W2564896970 @default.
- W4381232531 cites W2571125558 @default.
- W4381232531 cites W2575211870 @default.
- W4381232531 cites W2579811554 @default.
- W4381232531 cites W2585282147 @default.
- W4381232531 cites W2621849512 @default.
- W4381232531 cites W2735113067 @default.
- W4381232531 cites W2735208204 @default.
- W4381232531 cites W2755788236 @default.
- W4381232531 cites W2761185493 @default.
- W4381232531 cites W2766118129 @default.
- W4381232531 cites W2767061598 @default.
- W4381232531 cites W2768413943 @default.
- W4381232531 cites W2784074326 @default.
- W4381232531 cites W2799569187 @default.
- W4381232531 cites W2804636211 @default.
- W4381232531 cites W2893432317 @default.
- W4381232531 cites W2895239867 @default.
- W4381232531 cites W2897793952 @default.
- W4381232531 cites W2913640586 @default.
- W4381232531 cites W2949734136 @default.
- W4381232531 cites W2979661946 @default.
- W4381232531 cites W2982066492 @default.
- W4381232531 cites W2998746814 @default.
- W4381232531 cites W3005881989 @default.
- W4381232531 cites W3007246056 @default.
- W4381232531 cites W3014176072 @default.
- W4381232531 cites W3025337533 @default.
- W4381232531 cites W3033562641 @default.
- W4381232531 cites W3041524780 @default.
- W4381232531 cites W3088981963 @default.
- W4381232531 cites W3101341860 @default.
- W4381232531 cites W3103306322 @default.
- W4381232531 cites W3103875067 @default.
- W4381232531 cites W3113329435 @default.
- W4381232531 cites W3127754674 @default.
- W4381232531 cites W3129515529 @default.
- W4381232531 cites W3132635904 @default.
- W4381232531 cites W3134003840 @default.
- W4381232531 cites W3134531697 @default.
- W4381232531 cites W3175911016 @default.
- W4381232531 cites W3183750288 @default.
- W4381232531 cites W3197138509 @default.
- W4381232531 cites W4211140371 @default.
- W4381232531 cites W4225379410 @default.
- W4381232531 cites W4226112427 @default.
- W4381232531 cites W4280621631 @default.
- W4381232531 doi "https://doi.org/10.1007/978-981-99-1923-9_9" @default.
- W4381232531 hasPublicationYear "2023" @default.