Matches in SemOpenAlex for { <https://semopenalex.org/work/W4381248876> ?p ?o ?g. }
- W4381248876 abstract "Cutaneous Crohn's disease (CCD), also known as metastatic Crohn's disease (CD), is one of the rarest and most challenging cutaneous manifestations of CD. It is characterized by non-caseating granulomatous inflammation of the skin at sites that are non-contiguous with the gastrointestinal (GI) tract. Diagnosis of CCD needs a high clinical suspicion since morphological presentation varies widely and lacks an apparent correlation to the activity of the luminal CD. The onset of CCD in patients without active GI CD is a particularly understudied phenomenon.We present a case series of a unique patient group who developed CCD while in remission from a luminal CD perspective, mainly after a proctocolectomy for Crohn's colitis. We also provide a literature review and summary of case reports of CCD after proctocolectomy.Our 4 adult patients diagnosed with CCD after proctocolectomy presented herein, were successfully treated with high-dose corticosteroids, followed by biologic therapy. Furthermore, a comprehensive review of CCD is provided regarding its pathogenesis, clinical presentation, differential diagnosis, and the evidence behind the available treatments.CCD should be considered in any CD patient presenting with skin lesions regardless of their disease activity status and history of proctocolectomy. The treatment remains challenging; biologics remain the cornerstone and a multidisciplinary approach is recommended. Larger randomized clinical trials are essential to determine the optimal treatment protocol and to improve outcomes." @default.
- W4381248876 created "2023-06-20" @default.
- W4381248876 creator A5009101070 @default.
- W4381248876 date "2023-01-01" @default.
- W4381248876 modified "2023-09-26" @default.
- W4381248876 title "Cutaneous Crohn’s disease after proctocolectomy for medically refractory colonic Crohn’s disease: a case series and review of the literature" @default.
- W4381248876 cites W1590842347 @default.
- W4381248876 cites W1812931466 @default.
- W4381248876 cites W1833434449 @default.
- W4381248876 cites W1969693577 @default.
- W4381248876 cites W1971121263 @default.
- W4381248876 cites W1976444258 @default.
- W4381248876 cites W1977161486 @default.
- W4381248876 cites W198019529 @default.
- W4381248876 cites W1984403238 @default.
- W4381248876 cites W1987651998 @default.
- W4381248876 cites W199459011 @default.
- W4381248876 cites W1996363151 @default.
- W4381248876 cites W1997371107 @default.
- W4381248876 cites W2005228530 @default.
- W4381248876 cites W2007218036 @default.
- W4381248876 cites W2008714425 @default.
- W4381248876 cites W2009138965 @default.
- W4381248876 cites W2011682925 @default.
- W4381248876 cites W2013157606 @default.
- W4381248876 cites W2017563594 @default.
- W4381248876 cites W2020184289 @default.
- W4381248876 cites W2022224731 @default.
- W4381248876 cites W2024188085 @default.
- W4381248876 cites W2025338227 @default.
- W4381248876 cites W2025728958 @default.
- W4381248876 cites W2033089231 @default.
- W4381248876 cites W2035864377 @default.
- W4381248876 cites W2042455736 @default.
- W4381248876 cites W2046306635 @default.
- W4381248876 cites W2048002942 @default.
- W4381248876 cites W2051299545 @default.
- W4381248876 cites W2053588348 @default.
- W4381248876 cites W2054777058 @default.
- W4381248876 cites W2062745584 @default.
- W4381248876 cites W2063985282 @default.
- W4381248876 cites W2064775548 @default.
- W4381248876 cites W2066071636 @default.
- W4381248876 cites W2067625985 @default.
- W4381248876 cites W2068657848 @default.
- W4381248876 cites W2072511475 @default.
- W4381248876 cites W2076565115 @default.
- W4381248876 cites W2076945241 @default.
- W4381248876 cites W2080450020 @default.
- W4381248876 cites W2090690637 @default.
- W4381248876 cites W2090846346 @default.
- W4381248876 cites W2090852381 @default.
- W4381248876 cites W2098681952 @default.
- W4381248876 cites W2100720850 @default.
- W4381248876 cites W2108419017 @default.
- W4381248876 cites W2121799407 @default.
- W4381248876 cites W2134145435 @default.
- W4381248876 cites W2138241063 @default.
- W4381248876 cites W2142453927 @default.
- W4381248876 cites W2165864117 @default.
- W4381248876 cites W2169233896 @default.
- W4381248876 cites W2204122738 @default.
- W4381248876 cites W2208219265 @default.
- W4381248876 cites W2437969677 @default.
- W4381248876 cites W2523706394 @default.
- W4381248876 cites W2562322949 @default.
- W4381248876 cites W2579076549 @default.
- W4381248876 cites W2606470589 @default.
- W4381248876 cites W2640926383 @default.
- W4381248876 cites W2749631484 @default.
- W4381248876 cites W2767238269 @default.
- W4381248876 cites W2773995904 @default.
- W4381248876 cites W2783854695 @default.
- W4381248876 cites W2792917444 @default.
- W4381248876 cites W2805905269 @default.
- W4381248876 cites W2885874960 @default.
- W4381248876 cites W2888121871 @default.
- W4381248876 cites W2914260165 @default.
- W4381248876 cites W2948542723 @default.
- W4381248876 cites W2966705319 @default.
- W4381248876 cites W2980332485 @default.
- W4381248876 cites W2987886040 @default.
- W4381248876 cites W2994814226 @default.
- W4381248876 cites W3061311684 @default.
- W4381248876 cites W3087012951 @default.
- W4381248876 cites W3120109484 @default.
- W4381248876 cites W3120183576 @default.
- W4381248876 cites W3123268316 @default.
- W4381248876 cites W3132743342 @default.
- W4381248876 cites W3158808069 @default.
- W4381248876 cites W3194543742 @default.
- W4381248876 cites W331908908 @default.
- W4381248876 doi "https://doi.org/10.20524/aog.2023.0811" @default.
- W4381248876 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37396002" @default.
- W4381248876 hasPublicationYear "2023" @default.
- W4381248876 type Work @default.
- W4381248876 citedByCount "0" @default.
- W4381248876 crossrefType "journal-article" @default.
- W4381248876 hasAuthorship W4381248876A5009101070 @default.
- W4381248876 hasBestOaLocation W43812488761 @default.