FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4381249816> ?p ?o ?g. }

• W4381249816 abstract "Abstract Chick embryos are a valuable model for studying immunity and vaccines. Therefore, it is crucial to investigate the molecular mechanism of the Mycoplasma gallisepticum (MG)-induced immune response in chick embryos for the prevention and control of MG. In this study, we screened for downregulated let-7d microRNA in MG-infected chicken embryonic lungs to explore its involvement in the innate immune mechanism against MG. Here, we demonstrated that low levels of let-7d are a protective mechanism for chicken embryo primary type II pneumocytes (CP-II) in the presence of MG. Specifically, we found that depressed levels of let-7 in CP-II cells reduced the adhesion capacity of MG. This suppressive effect was achieved through the activated mitogen-activated protein kinase phosphatase 1 (MKP1) target gene and the inactivated mitogen-activated protein kinase (MAPK) pathway. Furthermore, MG-induced hyperinflammation and cell death were both alleviated by downregulation of let-7d. In conclusion, chick embryos protect themselves against MG infection through the innate immune molecule let-7d, which may result from its function as an inhibitor of the MAPK pathway to effectively mitigate MG adhesion, the inflammatory response and cell apoptosis. This study may provide new insight into the development of vaccines against MG." @default.
• W4381249816 created "2023-06-20" @default.
• W4381249816 creator A5020487588 @default.
• W4381249816 creator A5020993810 @default.
• W4381249816 creator A5027046596 @default.
• W4381249816 creator A5035843341 @default.
• W4381249816 creator A5053899576 @default.
• W4381249816 creator A5057678466 @default.
• W4381249816 creator A5061181693 @default.
• W4381249816 creator A5080205215 @default.
• W4381249816 date "2023-06-19" @default.
• W4381249816 modified "2023-10-11" @default.
• W4381249816 title "Low let-7d microRNA levels in chick embryos enhance innate immunity against Mycoplasma gallisepticum by suppressing the mitogen-activated protein kinase pathway" @default.
• W4381249816 cites W1513687761 @default.
• W4381249816 cites W1965152588 @default.
• W4381249816 cites W2008538530 @default.
• W4381249816 cites W2024330785 @default.
• W4381249816 cites W2107277218 @default.
• W4381249816 cites W2119013116 @default.
• W4381249816 cites W2121916105 @default.
• W4381249816 cites W2151198021 @default.
• W4381249816 cites W2192080449 @default.
• W4381249816 cites W2285154398 @default.
• W4381249816 cites W2331269740 @default.
• W4381249816 cites W2540422658 @default.
• W4381249816 cites W2574764635 @default.
• W4381249816 cites W2605427154 @default.
• W4381249816 cites W2792479357 @default.
• W4381249816 cites W2805446759 @default.
• W4381249816 cites W2807691231 @default.
• W4381249816 cites W2896655969 @default.
• W4381249816 cites W2910451516 @default.
• W4381249816 cites W2911146680 @default.
• W4381249816 cites W2921451900 @default.
• W4381249816 cites W2943881886 @default.
• W4381249816 cites W2944292279 @default.
• W4381249816 cites W2986850228 @default.
• W4381249816 cites W2995164504 @default.
• W4381249816 cites W3007655722 @default.
• W4381249816 cites W3016581035 @default.
• W4381249816 cites W3029606718 @default.
• W4381249816 cites W3071603197 @default.
• W4381249816 cites W3087489075 @default.
• W4381249816 cites W3090714488 @default.
• W4381249816 cites W3091156538 @default.
• W4381249816 cites W3135911917 @default.
• W4381249816 cites W3165137116 @default.
• W4381249816 cites W3208112440 @default.
• W4381249816 cites W3208530317 @default.
• W4381249816 cites W4210932549 @default.
• W4381249816 cites W4289342416 @default.
• W4381249816 cites W4295210991 @default.
• W4381249816 cites W4304807937 @default.
• W4381249816 cites W4310679721 @default.
• W4381249816 doi "https://doi.org/10.1186/s13567-023-01178-6" @default.
• W4381249816 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37337278" @default.
• W4381249816 hasPublicationYear "2023" @default.
• W4381249816 type Work @default.
• W4381249816 citedByCount "0" @default.
• W4381249816 crossrefType "journal-article" @default.
• W4381249816 hasAuthorship W4381249816A5020487588 @default.
• W4381249816 hasAuthorship W4381249816A5020993810 @default.
• W4381249816 hasAuthorship W4381249816A5027046596 @default.
• W4381249816 hasAuthorship W4381249816A5035843341 @default.
• W4381249816 hasAuthorship W4381249816A5053899576 @default.
• W4381249816 hasAuthorship W4381249816A5057678466 @default.
• W4381249816 hasAuthorship W4381249816A5061181693 @default.
• W4381249816 hasAuthorship W4381249816A5080205215 @default.
• W4381249816 hasBestOaLocation W43812498161 @default.
• W4381249816 hasConcept C104317684 @default.
• W4381249816 hasConcept C127561419 @default.
• W4381249816 hasConcept C136449434 @default.
• W4381249816 hasConcept C184235292 @default.
• W4381249816 hasConcept C196843134 @default.
• W4381249816 hasConcept C203014093 @default.
• W4381249816 hasConcept C2778838687 @default.
• W4381249816 hasConcept C2781151156 @default.
• W4381249816 hasConcept C55493867 @default.
• W4381249816 hasConcept C57074206 @default.
• W4381249816 hasConcept C86803240 @default.
• W4381249816 hasConcept C8891405 @default.
• W4381249816 hasConcept C89423630 @default.
• W4381249816 hasConcept C95444343 @default.
• W4381249816 hasConcept C97029542 @default.
• W4381249816 hasConceptScore W4381249816C104317684 @default.
• W4381249816 hasConceptScore W4381249816C127561419 @default.
• W4381249816 hasConceptScore W4381249816C136449434 @default.
• W4381249816 hasConceptScore W4381249816C184235292 @default.
• W4381249816 hasConceptScore W4381249816C196843134 @default.
• W4381249816 hasConceptScore W4381249816C203014093 @default.
• W4381249816 hasConceptScore W4381249816C2778838687 @default.
• W4381249816 hasConceptScore W4381249816C2781151156 @default.
• W4381249816 hasConceptScore W4381249816C55493867 @default.
• W4381249816 hasConceptScore W4381249816C57074206 @default.
• W4381249816 hasConceptScore W4381249816C86803240 @default.
• W4381249816 hasConceptScore W4381249816C8891405 @default.
• W4381249816 hasConceptScore W4381249816C89423630 @default.
• W4381249816 hasConceptScore W4381249816C95444343 @default.
• W4381249816 hasConceptScore W4381249816C97029542 @default.
• W4381249816 hasFunder F4320321001 @default.

• next