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- W4381249972 abstract "Abstract Background Articular injection of mesenchymal stem cells (MSCs) has been applied to treat knee osteoarthritis (kOA), but its clinical outcomes are controversial. This study investigated whether an articular inflammatory microenvironment (AIM) impacts MSC-based therapy in a rat model of kOA. Methods The biological change of MSCs and the functional change of MSCs on chondrocytes were evaluated under AIM. The key mediator and mechanism for the AIM impact on MSC therapy were explored via gain- and loss-of-function approaches. Results The results showed that MSCs exerted potent anti-kOA effects in vivo and in vitro, but that this therapy become chondrodestructive if a chronic AIM was present. Mechanistically, the overexpression of MMP13 in the injected MSCs via a MAPKs-AP1 signaling axis was revealed as the underlying mechanism for the detriment outcome. Conclusions This study thus clarifies recent clinical findings while also suggesting a means to overcome any detrimental effects of MSC-based therapy while improving its efficacy." @default.
- W4381249972 created "2023-06-20" @default.
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- W4381249972 date "2023-06-19" @default.
- W4381249972 modified "2023-10-17" @default.
- W4381249972 title "Detrimental alteration of mesenchymal stem cells by an articular inflammatory microenvironment results in deterioration of osteoarthritis" @default.
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- W4381249972 doi "https://doi.org/10.1186/s12916-023-02923-6" @default.
- W4381249972 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37337188" @default.
- W4381249972 hasPublicationYear "2023" @default.