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- W4381251330 endingPage "1904" @default.
- W4381251330 startingPage "1887" @default.
- W4381251330 abstract "A single adenosine receptor gene (dAdoR) has been detected in Drosophila melanogaster. However, its function in different cell types of the nervous system is mostly unknown. Therefore, we overexpressed or silenced the dAdoR gene in eye photoreceptors, all neurons, or glial cells and examined the fitness of flies, the amount and daily pattern of sleep, and the influence of dAdoR silencing on Bruchpilot (BRP) presynaptic protein. Furthermore, we examined the dAdoR and brp gene expression in young and old flies. We found that a higher level of dAdoR in the retina photoreceptors, all neurons, and glial cells negatively influenced the survival rate and lifespan of male and female Drosophila in a cell-dependent manner and to a different extent depending on the age of the flies. In old flies, expression of both dAdoR and brp was higher than in young ones. An excess of dAdoR in neurons improved climbing in older individuals. It also influenced sleep by lengthening nighttime sleep and siesta. In turn, silencing of dAdoR decreased the lifespan of flies, although it increased the survival rate of young flies. It hindered the climbing of older males and females, but did not change sleep. Silencing also affected the daily pattern of BRP abundance, especially when dAdoR expression was decreased in glial cells. The obtained results indicate the role of adenosine and dAdoR in the regulation of fitness in flies that is based on communication between neurons and glial cells, and the effect of glial cells on synapses." @default.
- W4381251330 created "2023-06-20" @default.
- W4381251330 creator A5003369529 @default.
- W4381251330 creator A5006786374 @default.
- W4381251330 creator A5029457753 @default.
- W4381251330 creator A5062595753 @default.
- W4381251330 date "2023-06-19" @default.
- W4381251330 modified "2023-10-14" @default.
- W4381251330 title "Effects of adenosine receptor overexpression and silencing in neurons and glial cells on lifespan, fitness, and sleep of Drosophila melanogaster" @default.
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- W4381251330 doi "https://doi.org/10.1007/s00221-023-06649-y" @default.