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- W4381279443 abstract "Abstract Gastrointestinal motility disorders are one of the main pathogenic factors responsible for functional dyspepsia (FD). Platelet-derived growth factor receptor-α-positive (PDGFRα + ) cells participate in regulating gastrointestinal motility; however, the underlying mechanisms remain unclear. Herein, we aimed to assess the therapeutic effects of electroacupuncture (EA) and determine whether EA modulates the phospholipase C (PLC)-inositol-1,4,5-trisphosphate (PLC-IP 3 ) pathway in PDGFRα + cells to improve gastrointestinal motility disorders in FD. Accordingly, FD rats stimulated by tail-clamping were treated with EA (with or without PLC inhibitor U73122). We observed that the PLC-IP 3 pathway was modulated in PDGFRα + cells, which improved gastrointestinal motility in FD model rats. Based on western blotting and immunofluorescence assay results, EA increased the expression of PDGFRα + cells and promoted the expression of PLC, P-PLC, and IP 3 in the gastric sinuses of FD rats. U73122-mediated inhibition of PLC expression treatment considerably reduced the frequency of gastrointestinal motility. However, there was no significant difference between the effects of antagonist and antagonist + EA treatments; EA treatment was superior to antagonist and antagonist + EA treatment alone. Overall, these results suggest that EA could ameliorate gastrointestinal motility disorders in FD rats by activating the PLC-IP3 pathway in PDGFRα + cells." @default.
- W4381279443 created "2023-06-21" @default.
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- W4381279443 date "2023-05-30" @default.
- W4381279443 modified "2023-09-27" @default.
- W4381279443 title "Electroacupuncture Ameliorates Gastrointestinal Motility in Rats with Functional Dyspepsia Via PLC/IP3 Signaling" @default.
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- W4381279443 doi "https://doi.org/10.21203/rs.3.rs-2957278/v1" @default.
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