Matches in SemOpenAlex for { <https://semopenalex.org/work/W4381279998> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W4381279998 abstract "Abstract Background Tuberculosis continues to be a serious health problem, and drug-resistant tuberculosis is an increasing threat that directly impacts the tuberculosis control program. These can be prevented or controlled by combining several drugs with antituberculous activity. In the present study, an attempt is made to understand the combinatorial effect of two medicinal plant extracts i.e. Piper longum and Cressa cretica against Mycobacterium tuberculosis. Methodology 2D checkerboard assay was used to study the combinatorial effect of the crude extracts. The 2-∆∆Ct method was used to determine the changes in gene expression of selected genes rpoB, gyrA and gyrB involved in transcription and DNA replication and intrinsic resistance of Mycobacterium tuberculosis to front-line drugs. Results Determination of the effect on gene expression at the subminimum inhibitory concentration of the crude extracts. The required MIC concentration, 125 µg/ml, was inversely reduced up to 7 µg/ml for P. longum . Similarly, the required MIC concentration of 250µg/mL of C. cretica is reduced to 10µg/mL. Conclusions The relative change in gene expression for rpoB and gyrA was 2 and 4-fold, respectively, and 1-fold for gyrB. Further characterization of the downstream target genes and in vivo studies may provide the mode of action of these two anti-mycobacterial agents." @default.
- W4381279998 created "2023-06-21" @default.
- W4381279998 creator A5042087519 @default.
- W4381279998 creator A5062421451 @default.
- W4381279998 creator A5062885785 @default.
- W4381279998 creator A5073813091 @default.
- W4381279998 date "2023-05-30" @default.
- W4381279998 modified "2023-09-27" @default.
- W4381279998 title "Combined effect of anti-mycobacterial plant extracts and their inhibitory effect on RNA polymerase and DNA gyrase gene of Mycobacterium tuberculosis" @default.
- W4381279998 cites W1240628811 @default.
- W4381279998 cites W1500022645 @default.
- W4381279998 cites W1975938560 @default.
- W4381279998 cites W2016562927 @default.
- W4381279998 cites W2042207765 @default.
- W4381279998 cites W2052660926 @default.
- W4381279998 cites W2054868977 @default.
- W4381279998 cites W2064133695 @default.
- W4381279998 cites W2064943876 @default.
- W4381279998 cites W2077620426 @default.
- W4381279998 cites W2079097930 @default.
- W4381279998 cites W2103017729 @default.
- W4381279998 cites W2107340859 @default.
- W4381279998 cites W2108325995 @default.
- W4381279998 cites W2113001906 @default.
- W4381279998 cites W2123727763 @default.
- W4381279998 cites W2138432502 @default.
- W4381279998 cites W2149415226 @default.
- W4381279998 cites W2551260066 @default.
- W4381279998 cites W2595618202 @default.
- W4381279998 cites W2603623765 @default.
- W4381279998 cites W2621405323 @default.
- W4381279998 cites W2790031511 @default.
- W4381279998 cites W2795381168 @default.
- W4381279998 cites W2886129375 @default.
- W4381279998 cites W2895461480 @default.
- W4381279998 cites W2910724770 @default.
- W4381279998 cites W2953424608 @default.
- W4381279998 cites W2980256661 @default.
- W4381279998 cites W4229442011 @default.
- W4381279998 doi "https://doi.org/10.21203/rs.3.rs-2909092/v1" @default.
- W4381279998 hasPublicationYear "2023" @default.
- W4381279998 type Work @default.
- W4381279998 citedByCount "0" @default.
- W4381279998 crossrefType "posted-content" @default.
- W4381279998 hasAuthorship W4381279998A5042087519 @default.
- W4381279998 hasAuthorship W4381279998A5062421451 @default.
- W4381279998 hasAuthorship W4381279998A5062885785 @default.
- W4381279998 hasAuthorship W4381279998A5073813091 @default.
- W4381279998 hasBestOaLocation W43812799981 @default.
- W4381279998 hasConcept C104317684 @default.
- W4381279998 hasConcept C142724271 @default.
- W4381279998 hasConcept C167125095 @default.
- W4381279998 hasConcept C176947019 @default.
- W4381279998 hasConcept C2776306059 @default.
- W4381279998 hasConcept C2777975735 @default.
- W4381279998 hasConcept C2778340795 @default.
- W4381279998 hasConcept C2781069245 @default.
- W4381279998 hasConcept C501593827 @default.
- W4381279998 hasConcept C54355233 @default.
- W4381279998 hasConcept C547475151 @default.
- W4381279998 hasConcept C71924100 @default.
- W4381279998 hasConcept C86803240 @default.
- W4381279998 hasConcept C89423630 @default.
- W4381279998 hasConceptScore W4381279998C104317684 @default.
- W4381279998 hasConceptScore W4381279998C142724271 @default.
- W4381279998 hasConceptScore W4381279998C167125095 @default.
- W4381279998 hasConceptScore W4381279998C176947019 @default.
- W4381279998 hasConceptScore W4381279998C2776306059 @default.
- W4381279998 hasConceptScore W4381279998C2777975735 @default.
- W4381279998 hasConceptScore W4381279998C2778340795 @default.
- W4381279998 hasConceptScore W4381279998C2781069245 @default.
- W4381279998 hasConceptScore W4381279998C501593827 @default.
- W4381279998 hasConceptScore W4381279998C54355233 @default.
- W4381279998 hasConceptScore W4381279998C547475151 @default.
- W4381279998 hasConceptScore W4381279998C71924100 @default.
- W4381279998 hasConceptScore W4381279998C86803240 @default.
- W4381279998 hasConceptScore W4381279998C89423630 @default.
- W4381279998 hasLocation W43812799981 @default.
- W4381279998 hasOpenAccess W4381279998 @default.
- W4381279998 hasPrimaryLocation W43812799981 @default.
- W4381279998 hasRelatedWork W2054732217 @default.
- W4381279998 hasRelatedWork W2112174138 @default.
- W4381279998 hasRelatedWork W2122261512 @default.
- W4381279998 hasRelatedWork W2389254905 @default.
- W4381279998 hasRelatedWork W2938138842 @default.
- W4381279998 hasRelatedWork W2981874894 @default.
- W4381279998 hasRelatedWork W3163682376 @default.
- W4381279998 hasRelatedWork W3212831254 @default.
- W4381279998 hasRelatedWork W4200107538 @default.
- W4381279998 hasRelatedWork W4381279998 @default.
- W4381279998 isParatext "false" @default.
- W4381279998 isRetracted "false" @default.
- W4381279998 workType "article" @default.