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- W4381297645 abstract "Ovotesticular disorder of sexual differentiation (OT-DSD) is a rare condition defined by the presence of both testicular and ovarian elements in the same individual. Definitive diagnosis is made based on histological assessment of the gonad/s confirming both ovarian and testicular components. In this paper, we describe how a diagnosis of 46XX, OT-DSD was made in a 20-year-old individual with enlarged breasts and ambiguous genitalia. The initial impression was congenital adrenal hyperplasia (CAH) based on 46, XX karyotype and absence of testes on physical examination and imaging. However, biochemical tests were inconsistent with CAH, hence a more probable diagnosis of 46, XX OT-DSD was considered. The patient suffered from gender dysphoria and after extensive counseling, he decided to undergo gender-affirming surgery: laparoscopic excision of the left gonad, subtotal hysterectomy, bilateral mastectomy, and a masculinizing genitoplasty. Histopathology of the left gonad revealed an ovotestes which confirmed the diagnosis of 46, XX OT-DSD." @default.
- W4381297645 created "2023-06-21" @default.
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- W4381297645 date "2023-01-01" @default.
- W4381297645 modified "2023-09-27" @default.
- W4381297645 title "An approach to the management and care of an individual with 46, XX ovotesticular disorder of sexual differentiation" @default.
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- W4381297645 doi "https://doi.org/10.4103/pjog.pjog_6_23" @default.
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