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- W4381309822 abstract "The biomimetic formal synthesis of the antibiotic platensimycin for the treatment of infection by multidrug-resistant bacteria was accomplished starting from either ent-kaurenoic acid or grandiflorenic acid, each of which is a natural compound available in multigram scale from its natural source. Apart from the natural origin of the selected precursors, the keys of the described approach are the long-distance functionalization of ent-kaurenoic acid at C11 and the efficient protocol for the A-ring degradation of the diterpene framework." @default.
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- W4381309822 date "2023-06-20" @default.
- W4381309822 modified "2023-09-25" @default.
- W4381309822 title "Bioinspired Synthesis of Platensimycin from Natural <i>ent</i>-Kaurenoic Acids" @default.
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- W4381309822 doi "https://doi.org/10.1021/acs.orglett.3c01470" @default.
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