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- W4381330641 abstract "Every eukaryotic cell contains two, distinct multisubunit protein kinase complexes that each contain a TOR (target of rapamycin) protein as the catalytic subunit. These ensembles, designated TORC1 and TORC2, serve as nutrient and stress sensors, signal integrators, and regulators of cell growth and homeostasis, but they differ in their composition, localization, and function. TORC1, activated on the cytosolic surface of the vacuole (or, in mammalian cells, on the cytosolic surface of the lysosome), promotes biosynthesis and suppresses autophagy. TORC2, located primarily at the plasma membrane (PM), maintains the proper levels and bilayer distribution of all PM components (sphingolipids, glycerophospholipids, sterols, and integral membrane proteins), which are needed for the membrane expansion that accompanies cell growth and division and for combating insults to PM integrity. This review summarizes our current understanding of the assembly, structural features, subcellular distribution, and function and regulation of TORC2, obtained largely through studies conducted with Saccharomyces cerevisiae. Expected final online publication date for the Annual Review of Cell and Developmental Biology, Volume 39 is October 2023. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates." @default.
- W4381330641 created "2023-06-21" @default.
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- W4381330641 date "2023-06-20" @default.
- W4381330641 modified "2023-10-01" @default.
- W4381330641 title "Regulation of TORC2 Function and Localization in Yeast" @default.
- W4381330641 doi "https://doi.org/10.1146/annurev-cellbio-011723-030346" @default.
- W4381330641 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37339679" @default.
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