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- W4381332489 abstract "<h3>Introduction</h3> Lymphogranuloma venereum (LGV) incidence continues to rise in the United Kingdom, primarily among gay, bisexual or other men who have sex with men (GBMSM). Current treatment guidelines recommend twenty-one days of doxycycline, but recent evidence suggests shorter antibiotic duration is as effective. We evaluated clinical outcomes in a cohort of GBMSM with LGV treated with seven days of doxycycline. <h3>Methods</h3> We reviewed case notes of all LGV cases diagnosed at a South London sexual health service between November 2016 and September 2022 focusing on those treated with only seven days of doxycycline. Figure 1 demonstrates the case selection process. Anonymised data including demographics, clinical features, treatment information, and test-of-cure results were collected from the electronic patient records. <h3>Results</h3> Fifty-two cases in whom LGV-specific DNA was detected were treated with seven days of doxycycline 100mg twice daily. All were GBMSM, median age was 35 years (range 21–64); 21 (40%) were living with HIV and 18 (35%) had concomitant sexually transmitted infections. Thirty-four (65%) were asymptomatic, while 18 (35%) reported symptoms; 7 (13%) urethral symptoms, 11 (21%) anorectal symptoms, and 2 (4%) with other symptoms. Twenty-two (42%) were prescribed additional antimicrobials at presentation, however none were active against <i>Chlamydia trachomatis</i>. All 52 underwent follow-up testing (range 4 – 481 days); <i>C. trachomatis</i> was detected in one case, but negative for LGV-specific DNA, and so considered to be a reinfection. All other cases were <i>C. trachomatis</i> negative, indicating successful LGV eradication. <h3>Discussion</h3> These data suggest seven days of doxycycline is an effective treatment for asymptomatic and uncomplicated anogenital LGV infection. We observed no treatment failures, and shorter antibiotic treatment has many advantages including convenience, lower cost, fewer side effects and improved antimicrobial stewardship. Our data support the approach of offering a seven-day doxycycline course routinely for asymptomatic and clinically mild <i>C. trachomatis</i> infections, regardless of LGV status." @default.
- W4381332489 created "2023-06-21" @default.
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- W4381332489 date "2023-06-01" @default.
- W4381332489 modified "2023-09-27" @default.
- W4381332489 title "O18 Effective treatment of lymphogranuloma venereum with a seven-day course of doxycycline" @default.
- W4381332489 doi "https://doi.org/10.1136/sextrans-bashh-2023.18" @default.
- W4381332489 hasPublicationYear "2023" @default.
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