Matches in SemOpenAlex for { <https://semopenalex.org/work/W4381337197> ?p ?o ?g. }
Showing items 1 to 61 of
61
with 100 items per page.
- W4381337197 endingPage "79" @default.
- W4381337197 startingPage "71" @default.
- W4381337197 abstract "Rheumatoid Arthritis (RA) is an autoimmune inflammatory and degenerative disease affecting the joints and joint cartilage, with extra-articular manifestations. The chronicity of RA causes irreversible damage to the skeletal system and with a poorly understood pathogenesis, current management modalities are grossly limited. Pre-clinical studies on RA in Africa are plagued with scarcity and inaccessibility of research grants and funding, and this has negatively impacted interest in research. Also, inducting agents that mimic the true pathogenesis of diseases such as RA are limited. Therefore, there is a need to find readily available alternatives to promote research studies on RA in our environment. This study aimed to evaluate the rheumatoid arthritis disease activity index (RADAI) of formaldehyde induction (FIA) in comparison to collagen induction (CIA) of arthritis using twenty adult male Wistar rats which were grouped into 5 (A-E) (n=4). Group A, the control group had feed and water only. Groups B, C, and D had two doses of 0.1% formaldehyde (50µl, 100µl, and 200µl, respectively). Group E had 200µl of bovine CII-CFA emulsion (0.2mg/ml). Booster dosage was performed 9 days later by injecting 100µl of bovine CII-CFA emulsion (0.1mg/ml). Body weights, ankle measurements, and blood samples were taken on days 1, 16, and 48, before sacrificing the animals by cervical dislocation. Both ankles were rapidly dissected and processed for histological assessment using Modified Mankin System. We recorded a 100% mortality rate on high-dose formaldehyde administration (Group D), but no mortalities were seen in other groups. In low and moderate dosages of formaldehyde, RA induction was achieved and when compared to Collagen Induced Arthritis (CIA), there was no significant difference noted. We postulate that Formaldehyde Induced Arthritis (FIA) models can serve as a substitute for CIA mimicking the true pathogenesis seen in rheumatoid arthritis." @default.
- W4381337197 created "2023-06-21" @default.
- W4381337197 creator A5020302308 @default.
- W4381337197 creator A5040002311 @default.
- W4381337197 creator A5046435974 @default.
- W4381337197 creator A5052142939 @default.
- W4381337197 creator A5078044668 @default.
- W4381337197 creator A5092214881 @default.
- W4381337197 creator A5092214882 @default.
- W4381337197 date "2023-06-20" @default.
- W4381337197 modified "2023-10-05" @default.
- W4381337197 title "Assessment of Formaldehyde-Induced Arthritis (FIA) using Modified Rheumatoid Arthritis Disease Activity Index (RADAI) on Adult Male Wistar Rats" @default.
- W4381337197 doi "https://doi.org/10.9734/air/2023/v24i5960" @default.
- W4381337197 hasPublicationYear "2023" @default.
- W4381337197 type Work @default.
- W4381337197 citedByCount "0" @default.
- W4381337197 crossrefType "journal-article" @default.
- W4381337197 hasAuthorship W4381337197A5020302308 @default.
- W4381337197 hasAuthorship W4381337197A5040002311 @default.
- W4381337197 hasAuthorship W4381337197A5046435974 @default.
- W4381337197 hasAuthorship W4381337197A5052142939 @default.
- W4381337197 hasAuthorship W4381337197A5078044668 @default.
- W4381337197 hasAuthorship W4381337197A5092214881 @default.
- W4381337197 hasAuthorship W4381337197A5092214882 @default.
- W4381337197 hasBestOaLocation W43813371971 @default.
- W4381337197 hasConcept C126322002 @default.
- W4381337197 hasConcept C141071460 @default.
- W4381337197 hasConcept C203014093 @default.
- W4381337197 hasConcept C2777077863 @default.
- W4381337197 hasConcept C2777575956 @default.
- W4381337197 hasConcept C2778640784 @default.
- W4381337197 hasConcept C2780942790 @default.
- W4381337197 hasConcept C71924100 @default.
- W4381337197 hasConceptScore W4381337197C126322002 @default.
- W4381337197 hasConceptScore W4381337197C141071460 @default.
- W4381337197 hasConceptScore W4381337197C203014093 @default.
- W4381337197 hasConceptScore W4381337197C2777077863 @default.
- W4381337197 hasConceptScore W4381337197C2777575956 @default.
- W4381337197 hasConceptScore W4381337197C2778640784 @default.
- W4381337197 hasConceptScore W4381337197C2780942790 @default.
- W4381337197 hasConceptScore W4381337197C71924100 @default.
- W4381337197 hasIssue "5" @default.
- W4381337197 hasLocation W43813371971 @default.
- W4381337197 hasOpenAccess W4381337197 @default.
- W4381337197 hasPrimaryLocation W43813371971 @default.
- W4381337197 hasRelatedWork W1955143826 @default.
- W4381337197 hasRelatedWork W2005464927 @default.
- W4381337197 hasRelatedWork W2077699888 @default.
- W4381337197 hasRelatedWork W2155702314 @default.
- W4381337197 hasRelatedWork W2340014349 @default.
- W4381337197 hasRelatedWork W2373757429 @default.
- W4381337197 hasRelatedWork W3023528495 @default.
- W4381337197 hasRelatedWork W3030951269 @default.
- W4381337197 hasRelatedWork W4247887685 @default.
- W4381337197 hasRelatedWork W71700122 @default.
- W4381337197 hasVolume "24" @default.
- W4381337197 isParatext "false" @default.
- W4381337197 isRetracted "false" @default.
- W4381337197 workType "article" @default.