Matches in SemOpenAlex for { <https://semopenalex.org/work/W4381378105> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W4381378105 abstract "Pain associated with diabetic peripheral neuropathy (DPN) is treated medically with gabapentin/pregabalin, tricyclic antidepressants, and serotonin-norepinephrine reuptake inhibitors1 which are often not satisfactory long-term. Spinal Cord Stimulation (SCS) is an effective alternative per 3 randomized controlled trials (RCTs)2,3,4. We reviewed and compared 3 published RCTs2,3,4 comparing SCS to conventional treatments for painful DPN in subjects with mostly type 2 diabetes (Table 1). Study outcome measures included a composite primary endpoint where patients could be identified as treatment responders by reduction in pain diary scores or Patient Global Impression of Change, ≥50% reduction in VAS measurement for pain, and a compound primary endpoint of ≥50% reduction in pain score and no neurologic decline. EQ5D questionnaires were used to assess Quality of Life. The difference in treatment success between SCS and control for the primary endpoint in the Intention-to-Treat populations ranged from 52 - 58%. Improvement in EQ5D index scores at 6 months ranged from 0.124 - 0.380. The similarity of outcomes in 3 RCTs2,3,4 demonstrate that SCS is an effective treatment modality for DPN pain compared with conventional medical approaches. Patients from 1 study4 have been followed-up to 18 months8 and patients in another2 up to 10 years9 with similar outcomes, demonstrating long-term benefits of SCS for patients with painful DPN. Disclosure B.W.Bode: Advisory Panel; Ascensia Diabetes Care, MannKind Corporation, Medtronic, Novo Nordisk, Zealand Pharma A/S, Research Support; Abbott Diabetes, Abvance Therapeutics, Better Therapeutics, Inc, Dexcom, Inc., Diasome, Dompé, Insulet Corporation, Lilly Diabetes, Medtronic, Novo Nordisk, Sanvita Medical, Senseonics, Provention Bio, Inc., REMD Biotherapeutics, ViaCyte, Inc., Xeris Pharmaceuticals, Inc., vTv Therapeutics, Speaker's Bureau; Abbott Diabetes, American Diabetes Association, Boehringer Ingelheim and Eli Lilly Alliance, Insulet Corporation, Lilly Diabetes, MannKind Corporation, Novo Nordisk, Sanofi, Xeris Pharmaceuticals, Inc., Stock/Shareholder; Glytec, LLC. G.Grunberger: Advisory Panel; CeQur SA, Nevro Corp., LifeScan Diabetes Institute, Speaker's Bureau; Eli Lilly and Company, Novo Nordisk. M.Fishman: Consultant; Abbott, Biotronik, Medtronic, Nevro Corp., Other Relationship; Medtronic, Abbott, Research Support; Abbott, Boston Scientific Corporation, Medtronic, Nalu, SGX Medical, Thermaquil, Biotronik, Stock/Shareholder; Celeri Health, Thermaquil. M.Murphy: Consultant; Medtronic, Relievant. R.A.Vigersky: Employee; Medtronic. L.Johanek: Employee; Medtronic. M.Larue: Employee; Medtronic. Funding Medtronic" @default.
- W4381378105 created "2023-06-21" @default.
- W4381378105 creator A5004911939 @default.
- W4381378105 creator A5005036709 @default.
- W4381378105 creator A5007787744 @default.
- W4381378105 creator A5034509828 @default.
- W4381378105 creator A5044307582 @default.
- W4381378105 creator A5085804778 @default.
- W4381378105 creator A5090151014 @default.
- W4381378105 date "2023-06-20" @default.
- W4381378105 modified "2023-09-26" @default.
- W4381378105 title "493-P: SCS for the Treatment of Painful DPN—Consistent Outcomes from Multiple RCTs" @default.
- W4381378105 doi "https://doi.org/10.2337/db23-493-p" @default.
- W4381378105 hasPublicationYear "2023" @default.
- W4381378105 type Work @default.
- W4381378105 citedByCount "0" @default.
- W4381378105 crossrefType "journal-article" @default.
- W4381378105 hasAuthorship W4381378105A5004911939 @default.
- W4381378105 hasAuthorship W4381378105A5005036709 @default.
- W4381378105 hasAuthorship W4381378105A5007787744 @default.
- W4381378105 hasAuthorship W4381378105A5034509828 @default.
- W4381378105 hasAuthorship W4381378105A5044307582 @default.
- W4381378105 hasAuthorship W4381378105A5085804778 @default.
- W4381378105 hasAuthorship W4381378105A5090151014 @default.
- W4381378105 hasConcept C126322002 @default.
- W4381378105 hasConcept C134018914 @default.
- W4381378105 hasConcept C142724271 @default.
- W4381378105 hasConcept C159110408 @default.
- W4381378105 hasConcept C168563851 @default.
- W4381378105 hasConcept C1862650 @default.
- W4381378105 hasConcept C203092338 @default.
- W4381378105 hasConcept C204787440 @default.
- W4381378105 hasConcept C2776468701 @default.
- W4381378105 hasConcept C2776608144 @default.
- W4381378105 hasConcept C2777180221 @default.
- W4381378105 hasConcept C2779951463 @default.
- W4381378105 hasConcept C2780764818 @default.
- W4381378105 hasConcept C42219234 @default.
- W4381378105 hasConcept C555293320 @default.
- W4381378105 hasConcept C71924100 @default.
- W4381378105 hasConceptScore W4381378105C126322002 @default.
- W4381378105 hasConceptScore W4381378105C134018914 @default.
- W4381378105 hasConceptScore W4381378105C142724271 @default.
- W4381378105 hasConceptScore W4381378105C159110408 @default.
- W4381378105 hasConceptScore W4381378105C168563851 @default.
- W4381378105 hasConceptScore W4381378105C1862650 @default.
- W4381378105 hasConceptScore W4381378105C203092338 @default.
- W4381378105 hasConceptScore W4381378105C204787440 @default.
- W4381378105 hasConceptScore W4381378105C2776468701 @default.
- W4381378105 hasConceptScore W4381378105C2776608144 @default.
- W4381378105 hasConceptScore W4381378105C2777180221 @default.
- W4381378105 hasConceptScore W4381378105C2779951463 @default.
- W4381378105 hasConceptScore W4381378105C2780764818 @default.
- W4381378105 hasConceptScore W4381378105C42219234 @default.
- W4381378105 hasConceptScore W4381378105C555293320 @default.
- W4381378105 hasConceptScore W4381378105C71924100 @default.
- W4381378105 hasIssue "Supplement_1" @default.
- W4381378105 hasLocation W43813781051 @default.
- W4381378105 hasOpenAccess W4381378105 @default.
- W4381378105 hasPrimaryLocation W43813781051 @default.
- W4381378105 hasRelatedWork W1135520780 @default.
- W4381378105 hasRelatedWork W1994637219 @default.
- W4381378105 hasRelatedWork W2013937421 @default.
- W4381378105 hasRelatedWork W2014185462 @default.
- W4381378105 hasRelatedWork W2080027527 @default.
- W4381378105 hasRelatedWork W2136445221 @default.
- W4381378105 hasRelatedWork W2336016151 @default.
- W4381378105 hasRelatedWork W4231230767 @default.
- W4381378105 hasRelatedWork W4239440955 @default.
- W4381378105 hasRelatedWork W2650104258 @default.
- W4381378105 hasVolume "72" @default.
- W4381378105 isParatext "false" @default.
- W4381378105 isRetracted "false" @default.
- W4381378105 workType "article" @default.