Matches in SemOpenAlex for { <https://semopenalex.org/work/W4381378466> ?p ?o ?g. }
Showing items 1 to 62 of
62
with 100 items per page.
- W4381378466 abstract "Intensive investigations have shown the profound metabolic beneficial effect of dietary intervention with plant polyphenols including curcumin and resveratrol. Recent studies have also shown that hepatic FGF21 is among the targets of dietary polyphenol intervention as well as intermittent fasting or nutritional restriction. Here we assessed whether hepatic FGF21 is required for dietary polyphenol intervention on metabolic homeostasis in mice on high fat high fructose diet (HFHF) challenge. Liver specific FGF21 null mice (Lfgf21-/-) were generated by mating Alb-Cre mice with Fgf21fl/fl mice. No appreciable defect on glucose disposal was observed in male or female Lfgf21-/- mice when they were fed with regular chow diet. In chow diet fed male but not female Lfgf21-/- mice, fat tolerance was impaired, associated with elevated fasting plasma TG level and reduced hepatic expression of Ehhadh and Ppargc1 (two downstream targets of FGF21). Following HFHF challenge, the control Fgf21fl/fl male mice exhibited response to 12-week curcumin intervention on reducing body weight, serum and hepatic TG elevation, and on improving fat tolerance. Those beneficial effects were absent in male Lfgf21-/- mice. In high fat diet challenged wild type mice, concomitant resveratrol intervention exhibited anticipated metabolic beneficial effect, associated with increased hepatic FGF21 mRNA and protein expression. Importantly, the metabolic beneficial effects of resveratrol intervention were observed in HFHF challenged Fgf21fl/fl mice but not in Lfgf21-/- mice. In wild type or transgenic female mice, we did not see appreciable beneficial effect with resveratrol intervention. Together we introduced a transgenic mouse model into the investigation of metabolic function of dietary intervention. We conclude that hepatic FGF21 is required for curcumin or resveratrol to exert its beneficial effect in male mice. Disclosure W.Shao: None. J.Feng: None. T.Jin: None. Funding Canadian Institutes of Health Research" @default.
- W4381378466 created "2023-06-21" @default.
- W4381378466 creator A5039579465 @default.
- W4381378466 creator A5082826760 @default.
- W4381378466 creator A5091429164 @default.
- W4381378466 date "2023-06-20" @default.
- W4381378466 modified "2023-09-24" @default.
- W4381378466 title "1654-P: Hepatic FGF21 Is Required for Curcumin and Resveratrol to Exert Their Metabolic Beneficial Effect in Male Mice" @default.
- W4381378466 doi "https://doi.org/10.2337/db23-1654-p" @default.
- W4381378466 hasPublicationYear "2023" @default.
- W4381378466 type Work @default.
- W4381378466 citedByCount "0" @default.
- W4381378466 crossrefType "journal-article" @default.
- W4381378466 hasAuthorship W4381378466A5039579465 @default.
- W4381378466 hasAuthorship W4381378466A5082826760 @default.
- W4381378466 hasAuthorship W4381378466A5091429164 @default.
- W4381378466 hasConcept C102230213 @default.
- W4381378466 hasConcept C104317684 @default.
- W4381378466 hasConcept C106646824 @default.
- W4381378466 hasConcept C126322002 @default.
- W4381378466 hasConcept C134018914 @default.
- W4381378466 hasConcept C141035611 @default.
- W4381378466 hasConcept C170493617 @default.
- W4381378466 hasConcept C2776816829 @default.
- W4381378466 hasConcept C2778250585 @default.
- W4381378466 hasConcept C55493867 @default.
- W4381378466 hasConcept C71924100 @default.
- W4381378466 hasConcept C74373430 @default.
- W4381378466 hasConcept C86803240 @default.
- W4381378466 hasConcept C98274493 @default.
- W4381378466 hasConceptScore W4381378466C102230213 @default.
- W4381378466 hasConceptScore W4381378466C104317684 @default.
- W4381378466 hasConceptScore W4381378466C106646824 @default.
- W4381378466 hasConceptScore W4381378466C126322002 @default.
- W4381378466 hasConceptScore W4381378466C134018914 @default.
- W4381378466 hasConceptScore W4381378466C141035611 @default.
- W4381378466 hasConceptScore W4381378466C170493617 @default.
- W4381378466 hasConceptScore W4381378466C2776816829 @default.
- W4381378466 hasConceptScore W4381378466C2778250585 @default.
- W4381378466 hasConceptScore W4381378466C55493867 @default.
- W4381378466 hasConceptScore W4381378466C71924100 @default.
- W4381378466 hasConceptScore W4381378466C74373430 @default.
- W4381378466 hasConceptScore W4381378466C86803240 @default.
- W4381378466 hasConceptScore W4381378466C98274493 @default.
- W4381378466 hasIssue "Supplement_1" @default.
- W4381378466 hasLocation W43813784661 @default.
- W4381378466 hasOpenAccess W4381378466 @default.
- W4381378466 hasPrimaryLocation W43813784661 @default.
- W4381378466 hasRelatedWork W2049677921 @default.
- W4381378466 hasRelatedWork W2077799214 @default.
- W4381378466 hasRelatedWork W2104655808 @default.
- W4381378466 hasRelatedWork W2104791454 @default.
- W4381378466 hasRelatedWork W2119493316 @default.
- W4381378466 hasRelatedWork W2122395778 @default.
- W4381378466 hasRelatedWork W2157000830 @default.
- W4381378466 hasRelatedWork W2894655487 @default.
- W4381378466 hasRelatedWork W3030588976 @default.
- W4381378466 hasRelatedWork W4303446503 @default.
- W4381378466 hasVolume "72" @default.
- W4381378466 isParatext "false" @default.
- W4381378466 isRetracted "false" @default.
- W4381378466 workType "article" @default.