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- W4381382971 abstract "Here we report the coupling of a cyclic peptide (VH4127) targeting the low density lipoprotein (LDL) receptor (LDLR) noncompetitively to cucurbit[7]uril (CB[7]) to develop a new kind of drug delivery system (DDS), namely, CB[7]-VH4127, with maintained binding affinity to the LDLR. To evaluate the uptake potential of this bismacrocyclic compound, another conjugate was prepared comprising a high-affinity group for CB[7] (adamantyl(Ada)-amine) coupled to the fluorescent tracker Alexa680 (A680). The resulting A680-Ada·CB[7]-VH4127 supramolecular complex demonstrated conserved LDLR-binding potential and improved LDLR-mediated endocytosis and intracellular accumulation potential in LDLR-expressing cells. The combination of two technologies, namely, monofunctionalized CB[7] and the VH4127 LDLR-targeting peptide, opens new avenues in terms of targeting and intracellular delivery to LDLR-expressing tissues or tumors. The versatile transport capacity of CB[7], known to bind a large spectrum of bioactive or functional compounds, makes this new DDS suitable for a wide range of therapeutic or imaging applications." @default.
- W4381382971 created "2023-06-21" @default.
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- W4381382971 date "2023-06-20" @default.
- W4381382971 modified "2023-10-16" @default.
- W4381382971 title "Preparation and <i>In Vitro</i> Validation of a Cucurbit[7]uril-Peptide Conjugate Targeting the LDL Receptor" @default.
- W4381382971 cites W1781421830 @default.
- W4381382971 cites W1808138581 @default.
- W4381382971 cites W1977379679 @default.
- W4381382971 cites W1982810365 @default.
- W4381382971 cites W1983792486 @default.
- W4381382971 cites W2008348255 @default.
- W4381382971 cites W2009071379 @default.
- W4381382971 cites W2016384435 @default.
- W4381382971 cites W2017397185 @default.
- W4381382971 cites W2020451019 @default.
- W4381382971 cites W2022148362 @default.
- W4381382971 cites W2025688309 @default.
- W4381382971 cites W2031395392 @default.
- W4381382971 cites W2037639872 @default.
- W4381382971 cites W2037714518 @default.
- W4381382971 cites W2038471787 @default.
- W4381382971 cites W2050557745 @default.
- W4381382971 cites W2068303603 @default.
- W4381382971 cites W2074149397 @default.
- W4381382971 cites W2075617973 @default.
- W4381382971 cites W2076907924 @default.
- W4381382971 cites W2080737507 @default.
- W4381382971 cites W2081463025 @default.
- W4381382971 cites W2084744450 @default.
- W4381382971 cites W2088396668 @default.
- W4381382971 cites W2091068412 @default.
- W4381382971 cites W2091242259 @default.
- W4381382971 cites W2100974520 @default.
- W4381382971 cites W2106346416 @default.
- W4381382971 cites W2110943393 @default.
- W4381382971 cites W2131074035 @default.
- W4381382971 cites W2134586168 @default.
- W4381382971 cites W2135129422 @default.
- W4381382971 cites W2135860971 @default.
- W4381382971 cites W2138466097 @default.
- W4381382971 cites W2139902274 @default.
- W4381382971 cites W2152380893 @default.
- W4381382971 cites W2160134664 @default.
- W4381382971 cites W2192072986 @default.
- W4381382971 cites W2253050824 @default.
- W4381382971 cites W2293356923 @default.
- W4381382971 cites W2314501155 @default.
- W4381382971 cites W2396161336 @default.
- W4381382971 cites W2417706723 @default.
- W4381382971 cites W2521167514 @default.
- W4381382971 cites W2521477150 @default.
- W4381382971 cites W2559177805 @default.
- W4381382971 cites W2560173039 @default.
- W4381382971 cites W2561423902 @default.
- W4381382971 cites W2587880409 @default.
- W4381382971 cites W2746176993 @default.
- W4381382971 cites W2753240448 @default.
- W4381382971 cites W2763661205 @default.
- W4381382971 cites W2766336180 @default.
- W4381382971 cites W2791376627 @default.
- W4381382971 cites W2797009151 @default.
- W4381382971 cites W2799365700 @default.
- W4381382971 cites W2802846069 @default.
- W4381382971 cites W2807702086 @default.
- W4381382971 cites W2809722643 @default.
- W4381382971 cites W2888807827 @default.
- W4381382971 cites W2888956146 @default.
- W4381382971 cites W2892163613 @default.
- W4381382971 cites W2894565833 @default.
- W4381382971 cites W2900424820 @default.
- W4381382971 cites W2902923697 @default.
- W4381382971 cites W2903603387 @default.
- W4381382971 cites W2947837477 @default.
- W4381382971 cites W2970314141 @default.
- W4381382971 cites W2980433869 @default.
- W4381382971 cites W2984543014 @default.
- W4381382971 cites W2984804743 @default.
- W4381382971 cites W3030997703 @default.
- W4381382971 cites W3041182114 @default.
- W4381382971 cites W3042677503 @default.
- W4381382971 cites W3090945082 @default.
- W4381382971 cites W3092641284 @default.