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• W4381432399 abstract "While several properties of bone and cartilage have been extensively studied with respect to knee osteoarthritis (OA), little is known about the relationship between these tissues. To assess the spatial correlation between cartilage thickness (CTh) and subchondral bone mineral density (sBMD) in OA femoral condyles of varying disease severities. CT arthrograms of 60 knees (from 27 men, 33 females, 64.3 ± 9.1 years old) with various severities of medial compartment OA were analyzed in this IRB-approved study (26 K/L2, 25 K/L3, and 9 K/L4). CT images were manually segmented to reconstruct 3D mesh models of the femoral bone and cartilage. 3D CTh maps were calculated based on the distance between bone and cartilage models, and 3D sBMD maps were obtained by averaging the CT intensity in the 3mm of subchondral bone adjacent to cartilage. The spatial correlation between CTh and sBMD maps was quantified for the medial and lateral condyles of each knee using a statistical index ranging between –1.0 (CTh is thinner where sBMD is denser) and 1.0 (CTh is thicker where sBMD is denser). For comparison with standard methods described in the literature, the average CTh and sBMD were calculated for the load-bearing region of the medial and lateral condyles. Wilcoxon rank-sum tests were used to compare the spatial correlations and the average CTh and sBMD between the three OA severity groups. The level of significance was set at 5%, with Bonferroni correction for multiple comparisons. In the medial compartment, the spatial relationship between CTh and sBMD progressively shifted from being positively correlated in K/L2 knees to negatively correlated in K/L4 knees, with statistically significant differences among the three groups (Table 1). The average CTh and sBMD showed irregular patterns, with differences among groups rarely reaching statistical significance. No statistically significant difference was observed in the lateral compartment. The spatial correlation supported the concept of bone and cartilage working as a functional unit and the alteration of this functional unit with OA. The positive correlation in early disease suggests a link with mechanical loading, where cartilage is thicker and bone denser in areas of larger mechanical stimulation. Interestingly, evaluating the CTh-sBMD relationship instead of CTh or sBMD individually showed more consistent patterns across the stages of the disease." @default.
• W4381432399 created "2023-06-21" @default.
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• W4381432399 date "2023-01-01" @default.
• W4381432399 modified "2023-09-27" @default.
• W4381432399 title "THE SPATIAL CORRELATION BETWEEN CARTILAGE THICKNESS AND SUBCHONDRAL BONE MINERAL DENSITY INVERSES WITH INCREASING OA SEVERITY" @default.
• W4381432399 doi "https://doi.org/10.1016/j.ostima.2023.100098" @default.
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