Matches in SemOpenAlex for { <https://semopenalex.org/work/W4381486980> ?p ?o ?g. }
- W4381486980 endingPage "104596" @default.
- W4381486980 startingPage "104596" @default.
- W4381486980 abstract "Biofilm formed by cariogenic microbes is the direct cause of dental caries, therefore, prevention of dental caries should be antibiofilm-based. Previously, we found the amyloid hexapeptides efficiently inhibited biofilm formation by aggregating into amyloid fibrils agglutinating microbes. This study aimed to select the most stable amyloid hexapeptide GIDLKI (GI6) and study its anticaries effect. Biofilms of multi-species bacteria, derived from mixed saliva, were cultured to evaluate the anti-biofilm formation effect of GI6. And then, the primary cariogenic bacterium Streptococcus mutans (S.mutans) was cultured in BHI with various pH, gradient concentrations of sucrose, glucose, and calcium ions to evaluate the anti-biofilm formation effects of GI6. Then models of human enamel block caries and twenty male SPF-SD rat caries induced by S. mutans biofilm were constructed, and confocal laser scanning microscopy, scanning electron microscopy, and micro-computed tomography were applied to investigate the antibiofilm formation, anticaries effects and use safety of GI6. GI6 could inhibit the multi-species bacteria biofilm formation and remained effective in anti-biofilm activity against S. mutans in environments closely related to caries. GI6 suppressed S. mutans biofilm formation and thus prevented or alleviated the development of caries in human tooth blocks and rat teeth. GI6 did not affect the intestinal flora, serum biochemical parameters, and the pathological changes of various organs. Amyloid hexapeptides, including but not limited to GI6, are novel effective anti-caries agents that can be used to prevent dental caries safely. This study explored the anti-biofilm formation and anti-caries effect of GI6 in vitro, highlighting the anti-biofilm formation therapy for dental caries and setting a foundation for the practical application of GI6 for the treatment of dental caries." @default.
- W4381486980 created "2023-06-22" @default.
- W4381486980 creator A5002430915 @default.
- W4381486980 creator A5021183813 @default.
- W4381486980 creator A5046420041 @default.
- W4381486980 creator A5071834880 @default.
- W4381486980 creator A5075667735 @default.
- W4381486980 date "2023-06-01" @default.
- W4381486980 modified "2023-10-12" @default.
- W4381486980 title "Amyloid hexapeptide prevent dental caries by antibiofilm formation" @default.
- W4381486980 cites W1533894881 @default.
- W4381486980 cites W2011698889 @default.
- W4381486980 cites W2060711055 @default.
- W4381486980 cites W2094425350 @default.
- W4381486980 cites W2167587239 @default.
- W4381486980 cites W2403271685 @default.
- W4381486980 cites W2419843077 @default.
- W4381486980 cites W2464203422 @default.
- W4381486980 cites W2600121819 @default.
- W4381486980 cites W2791385172 @default.
- W4381486980 cites W2801240942 @default.
- W4381486980 cites W2807030704 @default.
- W4381486980 cites W2887036416 @default.
- W4381486980 cites W2896607521 @default.
- W4381486980 cites W2960838646 @default.
- W4381486980 cites W2994900290 @default.
- W4381486980 cites W3025730071 @default.
- W4381486980 cites W3106996695 @default.
- W4381486980 cites W3116921899 @default.
- W4381486980 cites W3125336451 @default.
- W4381486980 cites W3162167104 @default.
- W4381486980 cites W3185617420 @default.
- W4381486980 cites W4211107393 @default.
- W4381486980 cites W4233435953 @default.
- W4381486980 cites W4280639161 @default.
- W4381486980 cites W4285154131 @default.
- W4381486980 cites W4292266520 @default.
- W4381486980 cites W4308158471 @default.
- W4381486980 cites W4309158118 @default.
- W4381486980 cites W3046748236 @default.
- W4381486980 doi "https://doi.org/10.1016/j.jdent.2023.104596" @default.
- W4381486980 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37353107" @default.
- W4381486980 hasPublicationYear "2023" @default.
- W4381486980 type Work @default.
- W4381486980 citedByCount "0" @default.
- W4381486980 crossrefType "journal-article" @default.
- W4381486980 hasAuthorship W4381486980A5002430915 @default.
- W4381486980 hasAuthorship W4381486980A5021183813 @default.
- W4381486980 hasAuthorship W4381486980A5046420041 @default.
- W4381486980 hasAuthorship W4381486980A5071834880 @default.
- W4381486980 hasAuthorship W4381486980A5075667735 @default.
- W4381486980 hasBestOaLocation W43814869801 @default.
- W4381486980 hasConcept C156887251 @default.
- W4381486980 hasConcept C179104552 @default.
- W4381486980 hasConcept C185592680 @default.
- W4381486980 hasConcept C199343813 @default.
- W4381486980 hasConcept C2777633098 @default.
- W4381486980 hasConcept C2778430296 @default.
- W4381486980 hasConcept C2779914569 @default.
- W4381486980 hasConcept C504460877 @default.
- W4381486980 hasConcept C523546767 @default.
- W4381486980 hasConcept C54355233 @default.
- W4381486980 hasConcept C55493867 @default.
- W4381486980 hasConcept C58123911 @default.
- W4381486980 hasConcept C71924100 @default.
- W4381486980 hasConcept C86803240 @default.
- W4381486980 hasConcept C89423630 @default.
- W4381486980 hasConceptScore W4381486980C156887251 @default.
- W4381486980 hasConceptScore W4381486980C179104552 @default.
- W4381486980 hasConceptScore W4381486980C185592680 @default.
- W4381486980 hasConceptScore W4381486980C199343813 @default.
- W4381486980 hasConceptScore W4381486980C2777633098 @default.
- W4381486980 hasConceptScore W4381486980C2778430296 @default.
- W4381486980 hasConceptScore W4381486980C2779914569 @default.
- W4381486980 hasConceptScore W4381486980C504460877 @default.
- W4381486980 hasConceptScore W4381486980C523546767 @default.
- W4381486980 hasConceptScore W4381486980C54355233 @default.
- W4381486980 hasConceptScore W4381486980C55493867 @default.
- W4381486980 hasConceptScore W4381486980C58123911 @default.
- W4381486980 hasConceptScore W4381486980C71924100 @default.
- W4381486980 hasConceptScore W4381486980C86803240 @default.
- W4381486980 hasConceptScore W4381486980C89423630 @default.
- W4381486980 hasLocation W43814869801 @default.
- W4381486980 hasLocation W43814869802 @default.
- W4381486980 hasOpenAccess W4381486980 @default.
- W4381486980 hasPrimaryLocation W43814869801 @default.
- W4381486980 hasRelatedWork W1985086436 @default.
- W4381486980 hasRelatedWork W2037619255 @default.
- W4381486980 hasRelatedWork W2052458935 @default.
- W4381486980 hasRelatedWork W2139703305 @default.
- W4381486980 hasRelatedWork W2190562529 @default.
- W4381486980 hasRelatedWork W2791468809 @default.
- W4381486980 hasRelatedWork W3107799423 @default.
- W4381486980 hasRelatedWork W3131527100 @default.
- W4381486980 hasRelatedWork W3153614243 @default.
- W4381486980 hasRelatedWork W3180011126 @default.
- W4381486980 isParatext "false" @default.
- W4381486980 isRetracted "false" @default.