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• W4381487605 abstract "Objective Little evidence exists on the effect of 17beta-estradiol plus norethisterone acetate on all the anthropometric indices. Hence, this systematic review and meta-analysis of Randomized Controlled Trials was conducted to give an evidence-based report on the effect of 17beta-estradiol plus norethisterone acetate on anthropometric indices. Methods The literature search was executed in databases including PubMed/Medline, Web of Science, Scopus, Embase, and Google Scholar to recognize clinical trials that examined the influence of 17beta-estradiol plus norethisterone acetate on obesity indices from database inception to Jan 2023. Results Combined findings were generated from 20 eligible articles. The meta-analysis showed that body weight (Weighted Mean Difference (WMD): −0.47 kg, 95% CI: −1.32, 0.37, p = 0.274), body fat (WMD: 0.16 kg, 95% CI: −1.26, 1.59, p = 0.821), WHR (WMD: 0.001 kg, 95% CI: −0.006, 1.15, p = 0.872), and LBM (WMD: −0.02 kg, 95% CI: −1.19, 1.15, p = 0.970) were not modified in DHEA group compared to the control, but BMI levels were significantly reduced in 17beta-estradiol plus norethisterone acetate group (WMD: −0.15 kg/m2, 95% CI: −0.30, −0.008, p = 0.039). Moreover, based on intervention duration (months), a more significant reduction in BMI was found in trials that were performed on studies with ˃3 months duration (WMD: −0.176 kg/m2) than studies with ≤ 3 months (WMD: 0.05 kg/m2). Conclusion Administration of 17beta-estradiol plus norethisterone acetate for more than 3 months results in a decrease in BMI, which helps to reduce cardiovascular disease risk." @default.
• W4381487605 created "2023-06-22" @default.
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• W4381487605 date "2023-08-01" @default.
• W4381487605 modified "2023-09-27" @default.
• W4381487605 title "The effect of 17beta-estradiol plus norethisterone acetate on anthropometric indices: A systematic review and meta-analysis of randomized controlled trials" @default.
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• W4381487605 doi "https://doi.org/10.1016/j.ejogrb.2023.06.019" @default.
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