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- W4381489010 abstract "Infection results when a pathogen produces host tissue damage and elicits an immune response. Critically ill patients experience immune activation secondary to both sterile and infectious insults, with overlapping clinical phenotypes and underlying immunological mechanisms. Patients also undergo a shift in microbiota with the emergence of pathogen-dominant microbiomes. Whilst the combination of inflammation and microbial shift has long challenged intensivists in the identification of true infection, the advent of highly sensitive molecular diagnostics has further confounded the diagnostic dilemma as the number of microbial detections increases. Given the key role of the host immune response in the development and definition of infection, profiling the host response offers the potential to help unravel the conundrum of distinguishing colonisation and sterile inflammation from true infection. This narrative review provides an overview of current approaches to distinguishing colonisation from infection using routinely available techniques and proposes matrices to support decision-making in this setting. In searching for new tools to better discriminate these states, the review turns to the understanding of the underlying pathobiology of the host response to infection. It then reviews the techniques available to assess this response in a clinically applicable context. It will cover techniques including profiling of transcriptome, protein expression, and immune functional assays, detailing the current state of knowledge in diagnostics along with the challenges and opportunities. The ultimate infection diagnostic tool will likely combine an assessment of both host immune response and sensitive pathogen detection to improve patient management and facilitate antimicrobial stewardship." @default.
- W4381489010 created "2023-06-22" @default.
- W4381489010 creator A5015571223 @default.
- W4381489010 creator A5047547922 @default.
- W4381489010 creator A5053371016 @default.
- W4381489010 creator A5066789024 @default.
- W4381489010 date "2023-06-21" @default.
- W4381489010 modified "2023-10-16" @default.
- W4381489010 title "Differentiating infection, colonisation, and sterile inflammation in critical illness: the emerging role of host-response profiling" @default.
- W4381489010 cites W1896739944 @default.
- W4381489010 cites W1981520342 @default.
- W4381489010 cites W1988623531 @default.
- W4381489010 cites W2046096315 @default.
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- W4381489010 cites W2050604996 @default.
- W4381489010 cites W2057574785 @default.
- W4381489010 cites W2061799973 @default.
- W4381489010 cites W2087774948 @default.
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- W4381489010 cites W2118183328 @default.
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- W4381489010 cites W2152344036 @default.
- W4381489010 cites W2153730691 @default.
- W4381489010 cites W2156900485 @default.
- W4381489010 cites W2161150914 @default.
- W4381489010 cites W2162960154 @default.
- W4381489010 cites W2164012665 @default.
- W4381489010 cites W2195240341 @default.
- W4381489010 cites W2296531152 @default.
- W4381489010 cites W2317889172 @default.
- W4381489010 cites W2341817708 @default.
- W4381489010 cites W2344294128 @default.
- W4381489010 cites W2404435360 @default.
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- W4381489010 cites W2948054035 @default.
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- W4381489010 cites W3210828635 @default.
- W4381489010 cites W4200363570 @default.
- W4381489010 cites W4224304272 @default.
- W4381489010 cites W4224313187 @default.
- W4381489010 cites W4225781871 @default.
- W4381489010 cites W4229450555 @default.
- W4381489010 cites W4233441564 @default.
- W4381489010 cites W4235256446 @default.
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- W4381489010 cites W4307280494 @default.
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- W4381489010 doi "https://doi.org/10.1007/s00134-023-07108-6" @default.
- W4381489010 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37344680" @default.
- W4381489010 hasPublicationYear "2023" @default.
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