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• W4381490387 abstract "The shape and deformability of red blood cells (RBCs) change with age, increasing their likelihood of becoming trapped in the splenic interendothelial slits (IESs) and being removed from the circulation. Existing evidence suggests that cell size and viscoelasticity vary with age, which impedes understanding of the mechanical retention of aged RBCs in the spleen. We present a computational study of the flow dynamics, shape changes, and mechanical retention of age-associated RBCs in the splenic IES. The results show that increasing RBC membrane viscosity slows the flow process early in aging, while increased sphericity due to cell size reduction eventually leads to RBC retention." @default.
• W4381490387 created "2023-06-22" @default.
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• W4381490387 date "2023-06-21" @default.
• W4381490387 modified "2023-10-17" @default.
• W4381490387 title "Computational investigation of flow dynamics and mechanical retention of age-associated red blood cells in the spleen" @default.
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• W4381490387 doi "https://doi.org/10.1103/physrevfluids.8.063103" @default.
• W4381490387 hasPublicationYear "2023" @default.
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