Matches in SemOpenAlex for { <https://semopenalex.org/work/W4381547121> ?p ?o ?g. }
- W4381547121 endingPage "8" @default.
- W4381547121 startingPage "1" @default.
- W4381547121 abstract "The 32 bp deletion in the chemokine receptor (C-C motif) 5 gene (CCR5Δ32) is a natural loss of function polymorphism that prevents the protein from locating on the cell surface. This genetic variation acts as a double-edge sword in the pathogenesis/defense mechanism of different health conditions, such as viral infections, autoimmune diseases, and cancers. Here, we evaluated the prevalence of the CCR5Δ32 polymorphism in the Turkmen population of Golestan province, northeast of Iran. Blood samples were collected from 400 randomly selected Turkmen populations (199 women and 201 men), and genomic DNA was extracted. Characterization of CCR5Δ32 genotypes was performed by PCR using primers flanking the 32-nucleotide deletion in the CCR5 gene. The amplified DNA fragments were visualized on 2% agarose gel electrophoresis with cybergreen staining under UV light. All individuals were of Turkmen ethnicity and lived in the Golestan province, northeast of Iran. The mean age of all participants was 35.46 years, with a 20-45 year range. All the studied subjects were healthy without any severe conditions such as autoimmune disease and viral infections. All individuals had no history of HIV infection. The PCR product visualization showed that all the samples are at the 330 bp size, which means the CCR5Δ32 allele was utterly absent from the study population. The presence of the CCR5Δ32 allele among Turkmens may be attributed to the admixture with European descent people. We conclude that the CCR5Δ32 polymorphism may be absent in the Iranian Turkmen population, and further studies with a large population are needed." @default.
- W4381547121 created "2023-06-22" @default.
- W4381547121 creator A5018531530 @default.
- W4381547121 creator A5020776663 @default.
- W4381547121 creator A5035536908 @default.
- W4381547121 creator A5041688110 @default.
- W4381547121 creator A5088056241 @default.
- W4381547121 date "2023-06-21" @default.
- W4381547121 modified "2023-09-26" @default.
- W4381547121 title "Prevalence of CCR5 Delta 32 Genetic Variant in the Turkmen Population of Golestan Province, Northeast of Iran" @default.
- W4381547121 cites W1550804120 @default.
- W4381547121 cites W1724443945 @default.
- W4381547121 cites W1883179250 @default.
- W4381547121 cites W1898841705 @default.
- W4381547121 cites W1936081603 @default.
- W4381547121 cites W1968196429 @default.
- W4381547121 cites W1980544268 @default.
- W4381547121 cites W1980626076 @default.
- W4381547121 cites W1981644527 @default.
- W4381547121 cites W1982788227 @default.
- W4381547121 cites W1983287226 @default.
- W4381547121 cites W1996233624 @default.
- W4381547121 cites W1997293960 @default.
- W4381547121 cites W2000013894 @default.
- W4381547121 cites W2005902712 @default.
- W4381547121 cites W2006688902 @default.
- W4381547121 cites W2007021820 @default.
- W4381547121 cites W2007645067 @default.
- W4381547121 cites W2010600354 @default.
- W4381547121 cites W2015659662 @default.
- W4381547121 cites W2017162467 @default.
- W4381547121 cites W2019879894 @default.
- W4381547121 cites W2021169005 @default.
- W4381547121 cites W2026444780 @default.
- W4381547121 cites W2028669706 @default.
- W4381547121 cites W2029776628 @default.
- W4381547121 cites W2039305059 @default.
- W4381547121 cites W2039616385 @default.
- W4381547121 cites W2040546223 @default.
- W4381547121 cites W2041551971 @default.
- W4381547121 cites W2047183726 @default.
- W4381547121 cites W2049482416 @default.
- W4381547121 cites W2052831663 @default.
- W4381547121 cites W2065904471 @default.
- W4381547121 cites W2069359683 @default.
- W4381547121 cites W2091024410 @default.
- W4381547121 cites W2095447689 @default.
- W4381547121 cites W2100097277 @default.
- W4381547121 cites W2100813429 @default.
- W4381547121 cites W2100901996 @default.
- W4381547121 cites W2101065129 @default.
- W4381547121 cites W2102472414 @default.
- W4381547121 cites W2105413159 @default.
- W4381547121 cites W2106321674 @default.
- W4381547121 cites W2114328141 @default.
- W4381547121 cites W2120996101 @default.
- W4381547121 cites W2131179327 @default.
- W4381547121 cites W2135395399 @default.
- W4381547121 cites W2142992633 @default.
- W4381547121 cites W2146591235 @default.
- W4381547121 cites W2147232303 @default.
- W4381547121 cites W2149967205 @default.
- W4381547121 cites W2154659235 @default.
- W4381547121 cites W2158545821 @default.
- W4381547121 cites W2165226694 @default.
- W4381547121 cites W2334003442 @default.
- W4381547121 cites W2418999895 @default.
- W4381547121 cites W2432096778 @default.
- W4381547121 cites W2462648536 @default.
- W4381547121 cites W2475094665 @default.
- W4381547121 cites W2561607968 @default.
- W4381547121 cites W2766220312 @default.
- W4381547121 cites W2771089180 @default.
- W4381547121 cites W2793132777 @default.
- W4381547121 cites W2906379378 @default.
- W4381547121 cites W2922425544 @default.
- W4381547121 cites W2981265571 @default.
- W4381547121 cites W2983010058 @default.
- W4381547121 cites W2994676413 @default.
- W4381547121 cites W3013345638 @default.
- W4381547121 cites W3029292308 @default.
- W4381547121 cites W3110425510 @default.
- W4381547121 cites W3200306410 @default.
- W4381547121 cites W4200135473 @default.
- W4381547121 cites W4200355264 @default.
- W4381547121 cites W4210804900 @default.
- W4381547121 cites W4281488642 @default.
- W4381547121 cites W7032323 @default.
- W4381547121 doi "https://doi.org/10.1155/2023/8823863" @default.
- W4381547121 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37388364" @default.
- W4381547121 hasPublicationYear "2023" @default.
- W4381547121 type Work @default.
- W4381547121 citedByCount "0" @default.
- W4381547121 crossrefType "journal-article" @default.
- W4381547121 hasAuthorship W4381547121A5018531530 @default.
- W4381547121 hasAuthorship W4381547121A5020776663 @default.
- W4381547121 hasAuthorship W4381547121A5035536908 @default.
- W4381547121 hasAuthorship W4381547121A5041688110 @default.