Matches in SemOpenAlex for { <https://semopenalex.org/work/W4381551350> ?p ?o ?g. }
- W4381551350 endingPage "32" @default.
- W4381551350 startingPage "26" @default.
- W4381551350 abstract "Background. MicroRNAs are short (20–22 nucleotides) non-coding RNAs that can posttranscriptionally regulate gene expression and are considered a regulator of the innate immunity system. Previously, many papers were published on the prediction of the interaction of the single-stranded (+)RNA virus SARS-CoV-2 with human microRNAs, as well as on the profile of circulating microRNAs in patients with COVID-19 of varying severity. However, no works are analyzing the possible contribution of miRNAs circulating in blood plasma to the severity of COVID-19. The aim. To study the features of the blood plasma microRNA profile of patients with different severity of the new coronavirus infection COVID-19 and to evaluate the possibility of microRNA interaction with the SARS-CoV-2 genome. Materials and methods . The results of NGS sequencing of plasma miRNAs of 3 recovered and 8 deceased patients with a highly severe form of COVID-19 were studied. Differentially presented microRNAs were determined using bioinformatics methods, and their binding sites with the SARS-CoV-2 genome were predicted. Results. This study demonstrates that in patients who have recovered from a highly severe form of COVID-19, the level of hsa-miR-19b-3p in the blood plasma is significantly increased. This microRNA makes up about 1.5 % of all circulating microRNAs and can bind to SARS-CoV-2 regions encoding proteins that suppress intracellular immunity mechanisms (NSP3, NSP9). In addition, this miRNA can stimulate the functional activity and proliferation of cytotoxic T-lymphocytes, one of the critical components of acquired cellular immunity against SARS-CoV-2. Conclusion. The results of the study can be used in the development of antiviral drugs based on RNA interference, as well as in the development of predictive test systems to optimize the tactics of treating patients with COVID-19." @default.
- W4381551350 created "2023-06-22" @default.
- W4381551350 creator A5031931382 @default.
- W4381551350 creator A5058785253 @default.
- W4381551350 date "2023-05-03" @default.
- W4381551350 modified "2023-10-18" @default.
- W4381551350 title "The role of circulating miR-19b miRNA in predicting the outcome of COVID-19" @default.
- W4381551350 cites W144423133 @default.
- W4381551350 cites W1967977640 @default.
- W4381551350 cites W2012463451 @default.
- W4381551350 cites W2019130238 @default.
- W4381551350 cites W2037589121 @default.
- W4381551350 cites W2038828239 @default.
- W4381551350 cites W2059073003 @default.
- W4381551350 cites W2102111081 @default.
- W4381551350 cites W2111663113 @default.
- W4381551350 cites W2171106047 @default.
- W4381551350 cites W2171604273 @default.
- W4381551350 cites W2179438025 @default.
- W4381551350 cites W2194201246 @default.
- W4381551350 cites W2407054407 @default.
- W4381551350 cites W2471786891 @default.
- W4381551350 cites W2908642543 @default.
- W4381551350 cites W2947244263 @default.
- W4381551350 cites W3009978482 @default.
- W4381551350 cites W3041266812 @default.
- W4381551350 cites W3086304026 @default.
- W4381551350 cites W3092296275 @default.
- W4381551350 cites W3092393238 @default.
- W4381551350 cites W3122856869 @default.
- W4381551350 cites W3131575773 @default.
- W4381551350 cites W3174536923 @default.
- W4381551350 cites W3215986649 @default.
- W4381551350 cites W4213200965 @default.
- W4381551350 cites W4225347762 @default.
- W4381551350 cites W4309650835 @default.
- W4381551350 cites W4313391979 @default.
- W4381551350 doi "https://doi.org/10.29413/abs.2023-8.2.3" @default.
- W4381551350 hasPublicationYear "2023" @default.
- W4381551350 type Work @default.
- W4381551350 citedByCount "0" @default.
- W4381551350 crossrefType "journal-article" @default.
- W4381551350 hasAuthorship W4381551350A5031931382 @default.
- W4381551350 hasAuthorship W4381551350A5058785253 @default.
- W4381551350 hasBestOaLocation W43815513501 @default.
- W4381551350 hasConcept C104317684 @default.
- W4381551350 hasConcept C126322002 @default.
- W4381551350 hasConcept C136449434 @default.
- W4381551350 hasConcept C141231307 @default.
- W4381551350 hasConcept C145059251 @default.
- W4381551350 hasConcept C159047783 @default.
- W4381551350 hasConcept C203014093 @default.
- W4381551350 hasConcept C2522874641 @default.
- W4381551350 hasConcept C2779134260 @default.
- W4381551350 hasConcept C2779341262 @default.
- W4381551350 hasConcept C3008058167 @default.
- W4381551350 hasConcept C524204448 @default.
- W4381551350 hasConcept C54355233 @default.
- W4381551350 hasConcept C60644358 @default.
- W4381551350 hasConcept C67705224 @default.
- W4381551350 hasConcept C70721500 @default.
- W4381551350 hasConcept C71924100 @default.
- W4381551350 hasConcept C86803240 @default.
- W4381551350 hasConcept C8891405 @default.
- W4381551350 hasConceptScore W4381551350C104317684 @default.
- W4381551350 hasConceptScore W4381551350C126322002 @default.
- W4381551350 hasConceptScore W4381551350C136449434 @default.
- W4381551350 hasConceptScore W4381551350C141231307 @default.
- W4381551350 hasConceptScore W4381551350C145059251 @default.
- W4381551350 hasConceptScore W4381551350C159047783 @default.
- W4381551350 hasConceptScore W4381551350C203014093 @default.
- W4381551350 hasConceptScore W4381551350C2522874641 @default.
- W4381551350 hasConceptScore W4381551350C2779134260 @default.
- W4381551350 hasConceptScore W4381551350C2779341262 @default.
- W4381551350 hasConceptScore W4381551350C3008058167 @default.
- W4381551350 hasConceptScore W4381551350C524204448 @default.
- W4381551350 hasConceptScore W4381551350C54355233 @default.
- W4381551350 hasConceptScore W4381551350C60644358 @default.
- W4381551350 hasConceptScore W4381551350C67705224 @default.
- W4381551350 hasConceptScore W4381551350C70721500 @default.
- W4381551350 hasConceptScore W4381551350C71924100 @default.
- W4381551350 hasConceptScore W4381551350C86803240 @default.
- W4381551350 hasConceptScore W4381551350C8891405 @default.
- W4381551350 hasIssue "2" @default.
- W4381551350 hasLocation W43815513501 @default.
- W4381551350 hasOpenAccess W4381551350 @default.
- W4381551350 hasPrimaryLocation W43815513501 @default.
- W4381551350 hasRelatedWork W1487857142 @default.
- W4381551350 hasRelatedWork W1556307916 @default.
- W4381551350 hasRelatedWork W2006838528 @default.
- W4381551350 hasRelatedWork W2008306603 @default.
- W4381551350 hasRelatedWork W2103515427 @default.
- W4381551350 hasRelatedWork W2141330728 @default.
- W4381551350 hasRelatedWork W2142935324 @default.
- W4381551350 hasRelatedWork W2188294308 @default.
- W4381551350 hasRelatedWork W2288992930 @default.
- W4381551350 hasRelatedWork W3209390153 @default.
- W4381551350 hasVolume "8" @default.