FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4381569338> ?p ?o ?g. }

• W4381569338 endingPage "e001342" @default.
• W4381569338 startingPage "e001342" @default.
• W4381569338 abstract "Introduction Immune checkpoint inhibitors (ICI) have improved outcomes for patients with many malignancies. However, these treatments are associated with immune-related adverse events, including pulmonary toxicity (pneumonitis). Pneumonitis is associated with significant short-term morbidity and mortality, but long-term outcomes are not well described. Methods We used the Vanderbilt Synthetic Derivative, a deidentified electronic health record database of >2.5 million patients seen at Vanderbilt, to identify patient charts that included treatment with pembrolizumab, nivolumab, ipilimumab, ipilimumab and nivolumab, atezolizumab or durvalumab by keyword search and ICD-10 codes for acute respiratory failure and/or bronchoalveolar lavage. We manually reviewed these charts and identified 78 subjects who met criteria for probable pneumonitis which included patients presenting with symptoms (dyspnoea, hypoxia, cough) and/or CT imaging consistent with this diagnosis. We collected data on demographics, ICI regimen, hospital admissions and long-term survival. Results Of the 78 patients (48 males; median age 64 (range 28–81)), 52 patients required at least 1 hospital admission related to pneumonitis. A total of 25 patients experienced poor short-term outcomes (including 6 referred to hospice, 11 discharged to rehabilitation and 9 deaths). There was no association with these outcomes by patient age (p=0.96), sex (p=0.60), smoking status (p=0.63) or cancer type (p=0.13). Median duration of follow-up was 8.3 months (range 0.2–110.6 months), and 29 patients (37%) were alive at last follow-up. Patients admitted to the hospital were more likely to die (p=0.002) and less likely to receive additional treatment (p<0.0001) or survive for ≥12 months with no evidence of disease (p=0.02). There were no differences in long-term outcomes for patients with underlying pulmonary comorbidities. Discussion ICI-pneumonitis has a high likelihood of causing hospitalisation and poor outcomes, including death. While there appears to be no difference in outcomes for patients with underling pulmonary comorbidities, those requiring admission have worse outcomes." @default.
• W4381569338 created "2023-06-22" @default.
• W4381569338 creator A5025067315 @default.
• W4381569338 creator A5032953403 @default.
• W4381569338 creator A5046756619 @default.
• W4381569338 date "2023-04-01" @default.
• W4381569338 modified "2023-09-23" @default.
• W4381569338 title "Long-term outcomes in patients with immune checkpoint inhibitor induced pneumonitis" @default.
• W4381569338 cites W2480035212 @default.
• W4381569338 cites W2618641368 @default.
• W4381569338 cites W2736166064 @default.
• W4381569338 cites W2759963646 @default.
• W4381569338 cites W2768429453 @default.
• W4381569338 cites W2789465165 @default.
• W4381569338 cites W2804344673 @default.
• W4381569338 cites W2804749198 @default.
• W4381569338 cites W2885781276 @default.
• W4381569338 cites W2889758875 @default.
• W4381569338 cites W2891486030 @default.
• W4381569338 cites W2891633409 @default.
• W4381569338 cites W2895543265 @default.
• W4381569338 cites W2902441602 @default.
• W4381569338 cites W2903585288 @default.
• W4381569338 cites W2942264107 @default.
• W4381569338 cites W2965778028 @default.
• W4381569338 cites W2971634681 @default.
• W4381569338 cites W2972642313 @default.
• W4381569338 cites W2982536504 @default.
• W4381569338 cites W2989956470 @default.
• W4381569338 cites W3005570342 @default.
• W4381569338 cites W3009082159 @default.
• W4381569338 cites W3108518804 @default.
• W4381569338 cites W3119307462 @default.
• W4381569338 doi "https://doi.org/10.1136/bmjresp-2022-001342" @default.
• W4381569338 hasPublicationYear "2023" @default.
• W4381569338 type Work @default.
• W4381569338 citedByCount "0" @default.
• W4381569338 crossrefType "journal-article" @default.
• W4381569338 hasAuthorship W4381569338A5025067315 @default.
• W4381569338 hasAuthorship W4381569338A5032953403 @default.
• W4381569338 hasAuthorship W4381569338A5046756619 @default.
• W4381569338 hasBestOaLocation W43815693381 @default.
• W4381569338 hasConcept C121608353 @default.
• W4381569338 hasConcept C126322002 @default.
• W4381569338 hasConcept C197934379 @default.
• W4381569338 hasConcept C2775949291 @default.
• W4381569338 hasConcept C2777701055 @default.
• W4381569338 hasConcept C2777714996 @default.
• W4381569338 hasConcept C2777742743 @default.
• W4381569338 hasConcept C2779524853 @default.
• W4381569338 hasConcept C2780030458 @default.
• W4381569338 hasConcept C2780057760 @default.
• W4381569338 hasConcept C2781433595 @default.
• W4381569338 hasConcept C71924100 @default.
• W4381569338 hasConceptScore W4381569338C121608353 @default.
• W4381569338 hasConceptScore W4381569338C126322002 @default.
• W4381569338 hasConceptScore W4381569338C197934379 @default.
• W4381569338 hasConceptScore W4381569338C2775949291 @default.
• W4381569338 hasConceptScore W4381569338C2777701055 @default.
• W4381569338 hasConceptScore W4381569338C2777714996 @default.
• W4381569338 hasConceptScore W4381569338C2777742743 @default.
• W4381569338 hasConceptScore W4381569338C2779524853 @default.
• W4381569338 hasConceptScore W4381569338C2780030458 @default.
• W4381569338 hasConceptScore W4381569338C2780057760 @default.
• W4381569338 hasConceptScore W4381569338C2781433595 @default.
• W4381569338 hasConceptScore W4381569338C71924100 @default.
• W4381569338 hasIssue "1" @default.
• W4381569338 hasLocation W43815693381 @default.
• W4381569338 hasOpenAccess W4381569338 @default.
• W4381569338 hasPrimaryLocation W43815693381 @default.
• W4381569338 hasRelatedWork W2750661428 @default.
• W4381569338 hasRelatedWork W2795152269 @default.
• W4381569338 hasRelatedWork W2925933490 @default.
• W4381569338 hasRelatedWork W3000961096 @default.
• W4381569338 hasRelatedWork W3046829154 @default.
• W4381569338 hasRelatedWork W3097089513 @default.
• W4381569338 hasRelatedWork W3103774939 @default.
• W4381569338 hasRelatedWork W3136244698 @default.
• W4381569338 hasRelatedWork W4221003897 @default.
• W4381569338 hasRelatedWork W4283697218 @default.
• W4381569338 hasVolume "10" @default.
• W4381569338 isParatext "false" @default.
• W4381569338 isRetracted "false" @default.
• W4381569338 workType "article" @default.