Matches in SemOpenAlex for { <https://semopenalex.org/work/W4381569786> ?p ?o ?g. }
Showing items 1 to 51 of
51
with 100 items per page.
- W4381569786 endingPage "58" @default.
- W4381569786 startingPage "53" @default.
- W4381569786 abstract "
 
 
 The problem of pharmacological protection of the body from complications of acute hypoxia, which develops in a confined unventilated space, confined space hypoxia (CSH), is relevant and requires immediate solution. Today, in terms of finding new drugs with high antihypoxic potential, the most promising are heterometallic complexes of germanium and 3d-metals (zinc, copper, manganese) with citric and tartaric acids. Toxicometric and screening studies proved high antihypoxic activity and harmlessness of the germanium – manganese (II) tartrate germanate (IV) coordination compound under the laboratory code OKAGERM-4.
 The aim of the study – to carry out comparative pharmacokinetic analysis of OKAGERM-4 at the stage of its elimination from the central chamber under normal conditions and in the modeled CSH.
 The experiments were performed on 48 nonlinear white rats of both sexes weighing 170–200 g, divided into two groups: control and experimental (rats in which CSH was modeled by placing them for 25 min in hermetic 10 cm3 sealed containers). In order to determine the pharmacokinetic profile, the level of OKAGERM-4 was determined by germanium content using the colorimetric method in blood serum 45 min, 3 h, 6 h and 24 h after a single intraperitoneal injection to rats at a dose of 96.8 mg/kg.
 Based on the semi-logarithmic curves obtained, a number of pharmacokinetic parameters were directly calculated, those that characterize the processes of OKAGERM-4 elimination from the central chamber: t1/2β (norm) 0.26 h ± 0.05 h; t1/2β (CSH) 0.23 h ± 0.03 h; K10 (norm) 11.33 h–1 ± 4.90 h–1; K10 (CSH) 11.83 h–1 ± 3.16 h–1; MRT (norm) 1.37 h ± 0.28 h; MRT (CSH) 1.42 h ± 0.18 h; Clt (normal) 7.30 mL/h/kg ± 0.89 mL/h/kg; Clt (CSH) 7.36 mL/h/kg ± 0.55 mL/h/kg.
 Thus, it has been experimentally established that the process of OKAGERM-4 elimination from the central chamber occurs approximately the same way regardless of the presence of hypoxic damage to the body.
 
 
" @default.
- W4381569786 created "2023-06-22" @default.
- W4381569786 creator A5026520518 @default.
- W4381569786 creator A5079972298 @default.
- W4381569786 date "2023-05-30" @default.
- W4381569786 modified "2023-10-18" @default.
- W4381569786 title "Elimination profile of the new antihypoxant OKAGERM-4 under normal conditions and confined space hypoxia model" @default.
- W4381569786 doi "https://doi.org/10.33250/17.01.053" @default.
- W4381569786 hasPublicationYear "2023" @default.
- W4381569786 type Work @default.
- W4381569786 citedByCount "0" @default.
- W4381569786 crossrefType "journal-article" @default.
- W4381569786 hasAuthorship W4381569786A5026520518 @default.
- W4381569786 hasAuthorship W4381569786A5079972298 @default.
- W4381569786 hasBestOaLocation W43815697861 @default.
- W4381569786 hasConcept C112705442 @default.
- W4381569786 hasConcept C185592680 @default.
- W4381569786 hasConcept C2777699559 @default.
- W4381569786 hasConcept C2779032678 @default.
- W4381569786 hasConcept C2780048820 @default.
- W4381569786 hasConcept C55493867 @default.
- W4381569786 hasConcept C86803240 @default.
- W4381569786 hasConcept C98274493 @default.
- W4381569786 hasConceptScore W4381569786C112705442 @default.
- W4381569786 hasConceptScore W4381569786C185592680 @default.
- W4381569786 hasConceptScore W4381569786C2777699559 @default.
- W4381569786 hasConceptScore W4381569786C2779032678 @default.
- W4381569786 hasConceptScore W4381569786C2780048820 @default.
- W4381569786 hasConceptScore W4381569786C55493867 @default.
- W4381569786 hasConceptScore W4381569786C86803240 @default.
- W4381569786 hasConceptScore W4381569786C98274493 @default.
- W4381569786 hasIssue "1" @default.
- W4381569786 hasLocation W43815697861 @default.
- W4381569786 hasOpenAccess W4381569786 @default.
- W4381569786 hasPrimaryLocation W43815697861 @default.
- W4381569786 hasRelatedWork W1982641735 @default.
- W4381569786 hasRelatedWork W2000317273 @default.
- W4381569786 hasRelatedWork W2063332120 @default.
- W4381569786 hasRelatedWork W2070193801 @default.
- W4381569786 hasRelatedWork W2071933018 @default.
- W4381569786 hasRelatedWork W2085286671 @default.
- W4381569786 hasRelatedWork W2091498915 @default.
- W4381569786 hasRelatedWork W2147152539 @default.
- W4381569786 hasRelatedWork W4299431451 @default.
- W4381569786 hasRelatedWork W2506253232 @default.
- W4381569786 hasVolume "17" @default.
- W4381569786 isParatext "false" @default.
- W4381569786 isRetracted "false" @default.
- W4381569786 workType "article" @default.