Matches in SemOpenAlex for { <https://semopenalex.org/work/W4381570306> ?p ?o ?g. }
Showing items 1 to 51 of
51
with 100 items per page.
- W4381570306 abstract "As the juncture between the body and environment, epithelia are both protective barriers and sensory interfaces that continually renew. To determine whether sensory neurons remodel to maintain homeostasis, we used in vivo two-photon imaging of somatosensory axons innervating Merkel cells in adult mouse skin. These touch receptors were highly plastic: 63% of Merkel cells and 89% of branches appeared, disappeared, grew, regressed and/or relocated over a month. Interestingly, Merkel-cell plasticity was synchronized across arbors during rapid epithelial turnover. When Merkel cells remodeled, the degree of plasticity between Merkel-cell clusters and their axons was well correlated. Moreover, branches were stabilized by Merkel-cell contacts. These findings highlight the role of epithelial-neural crosstalk in homeostatic remodeling. Conversely, axons were also dynamic when Merkel cells were stable, indicating that intrinsic neural mechanisms drive branch plasticity. Two terminal morphologies innervated Merkel cells: transient swellings called boutons, and stable cups termed kylikes. In Atoh1 knockout mice that lack Merkel cells, axons showed higher complexity than control mice, with exuberant branching and no kylikes. Thus, Merkel cells limit axonal branching and promote branch maturation. Together, these results reveal a previously unsuspected high degree of plasticity in somatosensory axons that is biased, but not solely dictated, by plasticity of target epithelial cells. This system provides a platform to identify intrinsic and extrinsic mechanisms that govern axonal patterning in epithelial homeostasis." @default.
- W4381570306 created "2023-06-22" @default.
- W4381570306 date "2023-05-30" @default.
- W4381570306 modified "2023-10-01" @default.
- W4381570306 title "Reviewer #4 (Public Review): Spatiotemporal dynamics of sensory neuron and Merkel-cell remodeling are decoupled during epidermal homeostasis" @default.
- W4381570306 doi "https://doi.org/10.7554/elife.87368.1.sa4" @default.
- W4381570306 hasPublicationYear "2023" @default.
- W4381570306 type Work @default.
- W4381570306 citedByCount "0" @default.
- W4381570306 crossrefType "peer-review" @default.
- W4381570306 hasBestOaLocation W43815703061 @default.
- W4381570306 hasConcept C105702510 @default.
- W4381570306 hasConcept C169760540 @default.
- W4381570306 hasConcept C172497186 @default.
- W4381570306 hasConcept C2777546739 @default.
- W4381570306 hasConcept C2778342957 @default.
- W4381570306 hasConcept C2780291066 @default.
- W4381570306 hasConcept C47611674 @default.
- W4381570306 hasConcept C54355233 @default.
- W4381570306 hasConcept C63645605 @default.
- W4381570306 hasConcept C86803240 @default.
- W4381570306 hasConcept C94487597 @default.
- W4381570306 hasConcept C95444343 @default.
- W4381570306 hasConceptScore W4381570306C105702510 @default.
- W4381570306 hasConceptScore W4381570306C169760540 @default.
- W4381570306 hasConceptScore W4381570306C172497186 @default.
- W4381570306 hasConceptScore W4381570306C2777546739 @default.
- W4381570306 hasConceptScore W4381570306C2778342957 @default.
- W4381570306 hasConceptScore W4381570306C2780291066 @default.
- W4381570306 hasConceptScore W4381570306C47611674 @default.
- W4381570306 hasConceptScore W4381570306C54355233 @default.
- W4381570306 hasConceptScore W4381570306C63645605 @default.
- W4381570306 hasConceptScore W4381570306C86803240 @default.
- W4381570306 hasConceptScore W4381570306C94487597 @default.
- W4381570306 hasConceptScore W4381570306C95444343 @default.
- W4381570306 hasLocation W43815703061 @default.
- W4381570306 hasOpenAccess W4381570306 @default.
- W4381570306 hasPrimaryLocation W43815703061 @default.
- W4381570306 hasRelatedWork W2006538840 @default.
- W4381570306 hasRelatedWork W2049761630 @default.
- W4381570306 hasRelatedWork W2099426569 @default.
- W4381570306 hasRelatedWork W2102038388 @default.
- W4381570306 hasRelatedWork W215450105 @default.
- W4381570306 hasRelatedWork W2766053937 @default.
- W4381570306 hasRelatedWork W2768681885 @default.
- W4381570306 hasRelatedWork W2883627903 @default.
- W4381570306 hasRelatedWork W3117566922 @default.
- W4381570306 hasRelatedWork W3117690776 @default.
- W4381570306 isParatext "false" @default.
- W4381570306 isRetracted "false" @default.
- W4381570306 workType "peer-review" @default.