Matches in SemOpenAlex for { <https://semopenalex.org/work/W4381570832> ?p ?o ?g. }
- W4381570832 endingPage "108" @default.
- W4381570832 startingPage "103" @default.
- W4381570832 abstract "Current research is focused on practical implications of magnesium-based implants largely due to their biodegradability and ability to promote bone healing and formation. However, the mechanism underlying the osteogenesis regulation by magnesium is still unclear. We describe cellular and molecular mechanisms underlying the effect of magnesium ions (Mg2+) on bone growth following the device implantation. The presented data demonstrate magnesium-induced activation of canonical Wnt/β-catenin signaling pathway in human bone marrow stromal cells resulting in their differentiation into osteoblasts, osteogenic effect and recovery of bone defects. We describe the role of the molecular mechanisms responsible for osteopromotive properties of Mg2+ and associated with unique transient receptor potential melastatin 7 (TRPM7) cation channels mediating the Mg2+ influx. TRPM7-mediated Mg2+ influx is important for platelet-derived growth factor (PDGF)-induced proliferation, adhesion, and migration of human osteoblasts, as well as for promotion of Mg2+-associated bone regeneration. We discuss the effect of Mg2+ on intracellular signaling processes, expression of the vascular endothelial growth factor (VEGF), hypoxia-inducible factor-2α, and peroxisome proliferator-activated receptor-γ coactivator 1α. Mg2+ can promote bone regeneration by enhancing the production of type X collagen and VEGF by osteogenic cells in bone marrow." @default.
- W4381570832 created "2023-06-22" @default.
- W4381570832 creator A5005539020 @default.
- W4381570832 creator A5031353950 @default.
- W4381570832 creator A5034211365 @default.
- W4381570832 creator A5057664802 @default.
- W4381570832 creator A5061552586 @default.
- W4381570832 creator A5087598043 @default.
- W4381570832 creator A5091673741 @default.
- W4381570832 date "2023-05-26" @default.
- W4381570832 modified "2023-09-27" @default.
- W4381570832 title "Biochemical aspects of magnesium-enhanced bone regeneration" @default.
- W4381570832 cites W1899960221 @default.
- W4381570832 cites W1966477091 @default.
- W4381570832 cites W1975682654 @default.
- W4381570832 cites W1978020953 @default.
- W4381570832 cites W1988201054 @default.
- W4381570832 cites W2000038050 @default.
- W4381570832 cites W2006729920 @default.
- W4381570832 cites W2034227864 @default.
- W4381570832 cites W2037694558 @default.
- W4381570832 cites W2040737445 @default.
- W4381570832 cites W2047830680 @default.
- W4381570832 cites W2054311522 @default.
- W4381570832 cites W2070604836 @default.
- W4381570832 cites W2078712719 @default.
- W4381570832 cites W2079055992 @default.
- W4381570832 cites W2087414338 @default.
- W4381570832 cites W2089254126 @default.
- W4381570832 cites W2120018864 @default.
- W4381570832 cites W2121861484 @default.
- W4381570832 cites W2127642119 @default.
- W4381570832 cites W2130607897 @default.
- W4381570832 cites W2134811016 @default.
- W4381570832 cites W2144100357 @default.
- W4381570832 cites W2183384304 @default.
- W4381570832 cites W2225772248 @default.
- W4381570832 cites W2254351007 @default.
- W4381570832 cites W2328003959 @default.
- W4381570832 cites W2510993966 @default.
- W4381570832 cites W2588263530 @default.
- W4381570832 cites W2730435325 @default.
- W4381570832 cites W2794132598 @default.
- W4381570832 cites W2806965041 @default.
- W4381570832 cites W2937887897 @default.
- W4381570832 cites W2947420593 @default.
- W4381570832 cites W2949316410 @default.
- W4381570832 cites W2992968481 @default.
- W4381570832 cites W3028418725 @default.
- W4381570832 cites W3034542395 @default.
- W4381570832 cites W3049393615 @default.
- W4381570832 cites W3109679928 @default.
- W4381570832 cites W3111554954 @default.
- W4381570832 cites W3119135628 @default.
- W4381570832 cites W3123297195 @default.
- W4381570832 cites W3195628333 @default.
- W4381570832 cites W4239898112 @default.
- W4381570832 cites W4285732959 @default.
- W4381570832 doi "https://doi.org/10.35401/2541-9897-2023-26-2-103-108" @default.
- W4381570832 hasPublicationYear "2023" @default.
- W4381570832 type Work @default.
- W4381570832 citedByCount "0" @default.
- W4381570832 crossrefType "journal-article" @default.
- W4381570832 hasAuthorship W4381570832A5005539020 @default.
- W4381570832 hasAuthorship W4381570832A5031353950 @default.
- W4381570832 hasAuthorship W4381570832A5034211365 @default.
- W4381570832 hasAuthorship W4381570832A5057664802 @default.
- W4381570832 hasAuthorship W4381570832A5061552586 @default.
- W4381570832 hasAuthorship W4381570832A5087598043 @default.
- W4381570832 hasAuthorship W4381570832A5091673741 @default.
- W4381570832 hasBestOaLocation W43815708321 @default.
- W4381570832 hasConcept C105702510 @default.
- W4381570832 hasConcept C126322002 @default.
- W4381570832 hasConcept C134018914 @default.
- W4381570832 hasConcept C137620995 @default.
- W4381570832 hasConcept C167734588 @default.
- W4381570832 hasConcept C16930146 @default.
- W4381570832 hasConcept C170493617 @default.
- W4381570832 hasConcept C171056886 @default.
- W4381570832 hasConcept C180361614 @default.
- W4381570832 hasConcept C185592680 @default.
- W4381570832 hasConcept C2775960820 @default.
- W4381570832 hasConcept C2777025900 @default.
- W4381570832 hasConcept C502942594 @default.
- W4381570832 hasConcept C55493867 @default.
- W4381570832 hasConcept C62478195 @default.
- W4381570832 hasConcept C71924100 @default.
- W4381570832 hasConcept C8337478 @default.
- W4381570832 hasConcept C86803240 @default.
- W4381570832 hasConcept C95444343 @default.
- W4381570832 hasConceptScore W4381570832C105702510 @default.
- W4381570832 hasConceptScore W4381570832C126322002 @default.
- W4381570832 hasConceptScore W4381570832C134018914 @default.
- W4381570832 hasConceptScore W4381570832C137620995 @default.
- W4381570832 hasConceptScore W4381570832C167734588 @default.
- W4381570832 hasConceptScore W4381570832C16930146 @default.
- W4381570832 hasConceptScore W4381570832C170493617 @default.
- W4381570832 hasConceptScore W4381570832C171056886 @default.