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- W4381597706 abstract "In the central nervous system (CNS), a large group of glial cells called astrocytes play important roles in both physiological and disease conditions. Astrocytes participate in the formation of neurovascular units and interact closely with other cells of the CNS, such as microglia and neurons. Stroke is a global disease with high mortality and disability rate, most of which are ischemic stroke. Significant strides in understanding astrocytes have been made over the past few decades. Astrocytes respond strongly to ischemic stroke through a process known as activation or reactivity. Given the important role played by reactive astrocytes (RAs) in different spatial and temporal aspects of ischemic stroke, there is a growing interest in the potential therapeutic role of astrocytes. Currently, interventions targeting astrocytes, such as mediating astrocyte polarization, reducing edema, regulating glial scar formation, and reprogramming astrocytes, have been proven in modulating the progression of ischemic stroke. The aforementioned potential interventions on astrocytes and the crosstalk between astrocytes and other cells of the CNS will be summarized in this review." @default.
- W4381597706 created "2023-06-23" @default.
- W4381597706 creator A5001374451 @default.
- W4381597706 creator A5002249994 @default.
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- W4381597706 creator A5046587422 @default.
- W4381597706 creator A5050520878 @default.
- W4381597706 creator A5058767538 @default.
- W4381597706 date "2023-06-21" @default.
- W4381597706 modified "2023-10-17" @default.
- W4381597706 title "Astrocytes in ischemic stroke: Crosstalk in central nervous system and therapeutic potential" @default.
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