FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4381597943> ?p ?o ?g. }

• W4381597943 abstract "The analysis of cannabinoids in whole blood is usually done by traditional mass spectrometry (MS) techniques, after offline cleanup or derivatization steps which can be lengthy, laborious, and expensive. We present a simple, fast, highly specific, and sensitive method for the determination of Δ9 -tetrahydrocannabinol (THC), cannabidiol (CBD), cannabinol (CBN), 11-hydroxy-Δ9 -tetrahydrocannabinol (11-OH-THC), and 11-nor-9-carboxy-Δ9 -tetrahydrocannabinol (THC-COOH) in 50 μL whole blood samples. After the addition of deuterated internal standards (IS) and a simple protein precipitation step, an online extraction of sample supernatants using turbulent flow chromatography (TurboFlow-Thermo Scientific) was carried out. Analytes were separated on a C18 analytical column and detected by LC-HRAM-Orbitrap-MS using a Thermo Scientific Q Exactive Focus MS system. MS detection was performed in polarity switching and selected ion monitoring (SIM) modes using five specific acquisition windows, at a resolution of 70,000 (FWHM). Total run time was about 10 min including preanalytical steps. Method validation was carried out by determining limit of detection (LOD), lower limit of quantitation (LLOQ), linearity range, analytical accuracy, intra-assay and interassay precision, carry-over, matrix effect, extraction recovery, and selectivity, for all analytes. Measurement uncertainties were also evaluated, and a decision rule was set with confidence for forensic purposes. The method may become suitable for clinical and forensic toxicology applications, taking advantage of the small matrix volume required, the simple and cost-effective sample preparation procedure, and the fast analytical run time. Performances were monitored over a long-term period and tested on 7620 driving under the influence of drugs (DUID) samples, including 641 positive samples." @default.
• W4381597943 created "2023-06-23" @default.
• W4381597943 creator A5010463929 @default.
• W4381597943 creator A5034287672 @default.
• W4381597943 creator A5072719536 @default.
• W4381597943 creator A5084768614 @default.
• W4381597943 creator A5089235004 @default.
• W4381597943 date "2023-06-21" @default.
• W4381597943 modified "2023-09-25" @default.
• W4381597943 title "Determination of cannabinoids in 50 μL whole blood samples by online extraction using turbulent flow chromatography and LC‐HRAM‐Orbitrap‐MS: Application on driving under the influence of drugs cases" @default.
• W4381597943 cites W1948393617 @default.
• W4381597943 cites W1965420039 @default.
• W4381597943 cites W2060121473 @default.
• W4381597943 cites W2087791805 @default.
• W4381597943 cites W2118772001 @default.
• W4381597943 cites W2292421631 @default.
• W4381597943 cites W2346912294 @default.
• W4381597943 cites W2462207341 @default.
• W4381597943 cites W2479325933 @default.
• W4381597943 cites W2584141931 @default.
• W4381597943 cites W2603733408 @default.
• W4381597943 cites W2606017268 @default.
• W4381597943 cites W2617706436 @default.
• W4381597943 cites W2785669369 @default.
• W4381597943 cites W2948661070 @default.
• W4381597943 cites W3015040331 @default.
• W4381597943 cites W3016204790 @default.
• W4381597943 cites W3038325336 @default.
• W4381597943 cites W3133364709 @default.
• W4381597943 cites W3172416309 @default.
• W4381597943 cites W3211885242 @default.
• W4381597943 cites W4213095113 @default.
• W4381597943 cites W4254185355 @default.
• W4381597943 doi "https://doi.org/10.1002/dta.3532" @default.
• W4381597943 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37343943" @default.
• W4381597943 hasPublicationYear "2023" @default.
• W4381597943 type Work @default.
• W4381597943 citedByCount "0" @default.
• W4381597943 crossrefType "journal-article" @default.
• W4381597943 hasAuthorship W4381597943A5010463929 @default.
• W4381597943 hasAuthorship W4381597943A5034287672 @default.
• W4381597943 hasAuthorship W4381597943A5072719536 @default.
• W4381597943 hasAuthorship W4381597943A5084768614 @default.
• W4381597943 hasAuthorship W4381597943A5089235004 @default.
• W4381597943 hasConcept C10390740 @default.
• W4381597943 hasConcept C106487976 @default.
• W4381597943 hasConcept C118552586 @default.
• W4381597943 hasConcept C119128265 @default.
• W4381597943 hasConcept C15744967 @default.
• W4381597943 hasConcept C162356407 @default.
• W4381597943 hasConcept C170493617 @default.
• W4381597943 hasConcept C185592680 @default.
• W4381597943 hasConcept C2776895053 @default.
• W4381597943 hasConcept C2776923573 @default.
• W4381597943 hasConcept C2777056318 @default.
• W4381597943 hasConcept C2778576202 @default.
• W4381597943 hasConcept C2780841973 @default.
• W4381597943 hasConcept C2780871563 @default.
• W4381597943 hasConcept C2781090866 @default.
• W4381597943 hasConcept C2908858883 @default.
• W4381597943 hasConcept C43617362 @default.
• W4381597943 hasConcept C4725764 @default.
• W4381597943 hasConcept C55493867 @default.
• W4381597943 hasConcept C74774607 @default.
• W4381597943 hasConceptScore W4381597943C10390740 @default.
• W4381597943 hasConceptScore W4381597943C106487976 @default.
• W4381597943 hasConceptScore W4381597943C118552586 @default.
• W4381597943 hasConceptScore W4381597943C119128265 @default.
• W4381597943 hasConceptScore W4381597943C15744967 @default.
• W4381597943 hasConceptScore W4381597943C162356407 @default.
• W4381597943 hasConceptScore W4381597943C170493617 @default.
• W4381597943 hasConceptScore W4381597943C185592680 @default.
• W4381597943 hasConceptScore W4381597943C2776895053 @default.
• W4381597943 hasConceptScore W4381597943C2776923573 @default.
• W4381597943 hasConceptScore W4381597943C2777056318 @default.
• W4381597943 hasConceptScore W4381597943C2778576202 @default.
• W4381597943 hasConceptScore W4381597943C2780841973 @default.
• W4381597943 hasConceptScore W4381597943C2780871563 @default.
• W4381597943 hasConceptScore W4381597943C2781090866 @default.
• W4381597943 hasConceptScore W4381597943C2908858883 @default.
• W4381597943 hasConceptScore W4381597943C43617362 @default.
• W4381597943 hasConceptScore W4381597943C4725764 @default.
• W4381597943 hasConceptScore W4381597943C55493867 @default.
• W4381597943 hasConceptScore W4381597943C74774607 @default.
• W4381597943 hasLocation W43815979431 @default.
• W4381597943 hasLocation W43815979432 @default.
• W4381597943 hasOpenAccess W4381597943 @default.
• W4381597943 hasPrimaryLocation W43815979431 @default.
• W4381597943 hasRelatedWork W1980539140 @default.
• W4381597943 hasRelatedWork W2048084775 @default.
• W4381597943 hasRelatedWork W2115218143 @default.
• W4381597943 hasRelatedWork W2195492704 @default.
• W4381597943 hasRelatedWork W2371154968 @default.
• W4381597943 hasRelatedWork W2571259047 @default.
• W4381597943 hasRelatedWork W2773453847 @default.
• W4381597943 hasRelatedWork W2950376438 @default.
• W4381597943 hasRelatedWork W3045254976 @default.
• W4381597943 hasRelatedWork W4381597943 @default.
• W4381597943 isParatext "false" @default.
• W4381597943 isRetracted "false" @default.

• next